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Arkady Khoutorsky

Academic title(s): 

Associate Professor

Arkady Khoutorsky
Contact Information
Email address: 
arkady.khoutorsky [at] mcgill.ca
Address: 

Department of Anesthesia, Ï㽶ÊÓƵ
McIntyre Medical Building, Room 1208
Montreal
QC
H3G 1Y6
514-398-5764

Department: 
Department of Anesthesia
Faculty of Dental Medicine and Oral Health Sciences.
Position: 
Associate Professor, Department of Anesthesia and Faculty of Dental Medicine and Oral Health Sciences
Research areas: 
Basic Science
Areas of interest: 

Research Interests

We are interested in understanding the molecular and cellular mechanisms underlying sensitization of peripheral and central nociceptive circuits in chronic pain conditions. Our research focuses on the role of gene expression mechanisms, particularly mÏ㽶ÊÓƵ translation, and structural changes via mTORC2 and extracellular matrix, in mediating the hyperalgesic states.

We are also interested in studying the role of the gut microbiome in fibromyalgia. We work in collaboration with Drs Yoram Shir and Amir Minerbi to deepen our understanding of changes in the gut microbiome in chronic pain in humans, investigate the role of these changes in mediating pain and related co-morbidities, and develop strategies targeting microbiome to alleviate pain.

We are also interested in understanding the role of polymorphisms in the APOE gene in chronic pain.

Specialization: 

Areas of expertise: 

  • Dysregulation of translational control and the development of chronic pain
  • Extracellular matrix (ECM) and matrix metalloproteinases (MMPs) in the regulation of spinal cord plasticity
  • Dysregulation of integrated stress response (ISR) pathway and pathophysiology of Fragile X syndrome
Group: 
Full Member
Salutation: 
Dr
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