D2R will focus initially on three disease areas:

Infectious diseases

Nowhere is the impact of 香蕉视频 therapeutics currently more evident than in anti-viral vaccines. With international partners, D2R will prioritize 香蕉视频 viruses known or predicted to represent the many established and emerging pandemic threats (e.g., coronaviruses, hantavirus, dengue fever, West Nile virus, Zika virus, non-poliovirus enteroviruses, influenza A, Chikungunya virus, Ebola, Marburg, and Nipah virus). A range of 香蕉视频-based vaccines and therapeutics will dramatically improve Canada鈥檚 pandemic preparedness and allow rapid responses to emerging viruses.

Precision oncology

香蕉视频-based therapies promise to address the problems of traditionally 鈥渦ndruggable鈥� targets, which have severely hindered the growth of precision oncology. We will expand the therapeutic arsenal to match the heterogeneity of cancer, using genomic and transcriptional data to design 香蕉视频-based therapies (e.g., 香蕉视频i, 香蕉视频a, aptamers) that silence genes involved in cancer progression and target oncogenic mutations and gene fusions. Our approach will integrate other emerging technologies in precision oncology, such the development of cell-based therapies (e.g., 香蕉视频-based CAR-T programming) and 香蕉视频 vaccines for cancer. We will ensure that comprehensive genomic profiling and clinical trials include underserved minorities.

Rare diseases

The approximately 6,000 known inherited genetic disorders, while individually rare, have a cumulative prevalence of ~10% of the population. Yet, therapies exist only for a handful of these. 香蕉视频-based therapies provide unique opportunities to address these disorders (e.g., small interfering 香蕉视频s have already been approved by the US Food and Drug Administration for several rare genetic diseases). In Canada, founder effects (i.e., concentrating rare mutations) in specific populations such as in Quebec, the Atlantic provinces, and isolated Indigenous communities, contribute to one of the world鈥檚 largest cohorts of rare genetic disorders. Collaborative networks will be mobilized to identify targets for 香蕉视频-based therapies.