香蕉视频

Alonso F, Li L, Fr茅maux I, Reinhardt DP, G茅not E. (2022). Fibrillin-1 regulates arteriole integrity in the retina.听Biomolecules聽12: 1330.听

*Muthu ML, *Tiedemann K, Fradette J, #Komarova SV, #Reinhardt DP, *Co-first authors contributed equally to this work, #Co-corresponding authors. (2022). Fibrillin-1 regulates white adipose tissue development, homeostasis, and function.听Matrix Biol聽110: 106-128.听

Zhang R-M, Tiedemann K, Dinesh NEH, Muthu ML, Komarova S, Ramkhelawon B, Reinhardt DP. (2022). Fibrillin-1 regulated miR-122 has a critical role in thoracic aortic aneurysm formation.听Cell Mol Life Sci聽79: 314.听

*Tiedemann K, *Muthu ML, #Reinhardt DP, #Komarova SV, *Co-first authors contributed equally to this work, #Co-corresponding authors. (2022). Male Marfan mice are predisposed to high fat diet induced obesity, diabetes, and fatty liver.听Am J Physiol Cell Physiol聽323: C354-C366.听

Dinesh NEH, Campeau PM, Reinhardt DP. (2022). Fibronectin isoforms in skeletal development and associated disorders.听Am J Physiol Cell Physiol聽323: C536-C549.听

Dinesh NEH, Campeau PM, Reinhardt DP. (2022). Pathomechanisms in corner fracture type spondylometaphyseal dysplasia.听MRM Insights.听

Mead TJ, Martin DR, Wang LW, Cain, S. A., Gulec C, Cahill E, Mauch J, Reinhardt DP, Lo CW, Baldock C, Apte SS. (2022). Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development.听eLife聽11: e71142.听

Boizot J, Minville-Walz M, Reinhardt DP, Bouschbacher M, Sommer P, Sigaudo-Roussel D, Debret R. (2022). FBN2 silencing recapitulates hypoxic conditions and induces elastic fiber impairment in human dermal fibroblasts.听Int J Mol Sci聽23: 1824.听

Camas茫o D, Li L, Drouin B, Lau C, Reinhardt DP, Mantovani D. (2022). Physiologically relevant platform for an advanced in vitro model of the vascular wall: focus on in situ fabrication and mechanical maturation.听In Vitro Models: 179-195.听

Balic Z, Misra S, Willard B, Reinhardt DP, Apte SS, Hubmacher D. (2021). Alternative splicing of the metalloprotease ADAMTS17 spacer regulates secretion and modulates autoproteolytic activity.听FASEB J聽35: e21310.听

C么t茅 E, Zhang R, Kaiser N, Reinhardt DP, Martin C. (2021). Annuloaortic ectasia in a dog: long-term follow-up and immunofluorescent study.听Vet Q聽41: 280-291.听

de Souza RB, Gyuricza IG, Cassiano LL, Farinha-Arcieri LE, Alvim Liberatore AM, Schuindt do Carmo S, Caldeira W, Cruz MV, Ribeiro AF, Tedesco RC, Reinhardt DP, Smith R, Jun Koh IH, Pereira LV. (2021). The mg螖lpn mouse model for Marfan syndrome recapitulates the ocular phenotypes of the disease.听Exp Eye Res聽204: 108461.听

de Souza RB, Kawahara EI, Farinha-Arcieri LE, Gerdes Gyuricza I, Neofiti-Papi B, Miranda-Rodrigues M, Cruz Grecco Teixeira M, Ribeiro Fernandes G, Barbarosa Lemes R, Reinhardt DP, Gouveia CH, Pereira LV. (2021). Hyperkyphosis is not dependent on bone mass and quality in the mouse model of Marfan syndrome.听Bone聽152: 116073.听

Shi Y, Jones W, Beatty W, Tan Q, Mecham R, Kumra H, Reinhardt DP, Gibson MA, Reilly MA, Rodriguez J, Bassnett S. (2021). Latent-transforming growth factor beta-binding protein-2 (LTBP-2) is required for longevity but not for development of zonular fibers.听Matrix Biol聽95: 15-31.听

Sun B, Tomita B, Salinger A, Tilvawala RR, Li L, Hakami H, Liu T, Tsoyi K, Rosas IO, Reinhardt DP, Thompson PR, Ho I-C. (2021). PAD2-mediated citrullination of fibulin-5 promotes elastogenesis.听Matrix Biol聽102: 70-84.听

Zhang RM, Zeyer KA, Odenthal N, Zhang Y, Reinhardt DP. (2021). The fibrillin-1 RGD motif post-transcriptionally regulates ERK1/2 signaling and fibroblast proliferation via miR-1208.听FASEB J聽35: e21598.听

Boel A, Burger J, Vanhomwegen M, Beyens A, Renard M, Barnhoorn S, Casteleyn C, Reinhardt DP, Descamps B, Vanhove C, van der Pluijm I, Coucke P, Willaert A, Essers J, Callewaert B. (2020). Slc2a10 knock-out mice deficient in ascorbic acid synthesis recapitulate aspects of arterial tortuosity syndrome and display mitochondrial respiration defects.听Hum Mol Genet聽29: 1476-1488.听

Muthu ML, Reinhardt DP. (2020). Fibrillin-1 and fibrillin-1-derived asprosin in adipose tissue function and metabolic disorders.听J Cell Commun Signal聽14: 159-173.听

Nelea V, Reinhardt DP. (2020). Biophysical techniques to analyze elastic tissue extracellular matrix proteins.听Methods Mol Biol聽2043: 213-235.听

Zhang R, Kumra H, Reinhardt DP. (2020). Quantification of extracellular matrix fiber systems related to ADAMTS proteins.听Methods Mol Biol聽2043: 237-250.听

*Kumra H, *Nelea V, Hakami H, Pagliuzza A, Djokic J, Xu J, Yanagisawa H, Reinhardt DP, *Co-first authors contributed equally to this work. (2019). Fibulin-4 exerts a dual role in LTBP-4L mediated matrix assembly and function.听Proc Natl Acad Sci U S A聽116: 20428-20437.听

*Zeyer KA, *Zhang RM, Kumra H, Hassan A, Reinhardt DP, *Co-first authors contributed equally to this work. (2019). The fibrillin-1 RGD integrin binding site regulates gene expression and cell function through micro香蕉视频s.听J Mol Biol聽431: 401-421.听

Burger J, van Vliet N, van Heijningen P, Kumra H, Kremers G-J, Alves M, van Cappellen G, Yanagisawa H, Reinhardt DP, Kanaar R, van der Pluijm I, Essers J. (2019). Fibulin-4 deficiency differentially affects cytoskeleton structure and dynamics as well as TGF尾 signaling.听Cell Signal聽58: 65-78.听

Costantini A, Valta H, Baratang NV, Yap P, Bertola DR, Yamamoto GL, Kim CA, Chen J, Wierenga KJ, Fanning EA, Escobar L, McWalter K, McLaughlin H, Willaert R, Begtrup A, Alm JJ, Reinhardt DP, M盲kitie O, Campeau PM. (2019). Novel fibronectin mutations expand the phenotype of the FN1-subtype of spondylometaphyseal dysplasia with "corner fractures".听Bone聽121: 163-171.听

Dinesh NEH, Reinhardt DP. (2019). Inflammation in thoracic aortic aneurysms.听Herz聽44: 138-146.听

Kumra H, Dinesh NEH, Reinhardt DP. (2019). Lessons from tracheal tube development for understanding congenital tracheal malformations.听Eur Respir J聽53: 1900127.听

Wang LW, Kutz WE, Mead TJ, Beene LC, Singh S, Jenkins MW, Reinhardt DP, Apte SS. (2019). Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage.听Matrix Biol聽77: 117-128.听

Yin X, Wanga S, Fellows AL, Barallobre-Barreiro J, Lu R, Davaapil H, Franken R, Fava M, Baig F, Skroblin P, Xing Q, Koolbergen DR, Groenink M, Zwinderman K, Balm R, de Vries CJ, Mulder BJ, Viner R, Jahangiri M, Reinhardt DP, Sinha S, de Waard V, Mayr M. (2019). Glycoproteomic analysis of the aortic extracellular matrix in Marfan patients.听Arterioscler Thromb Vasc Biol聽39: 1859-1873.听

Camas茫o D, Pezzoli D, Loy C, Kumra H, Levesque L, Reinhardt DP, Candiani G, Mantovani D. (2018). Increasing cell seeding density improves elastin expression and mechanical properties in collagen gel-based scaffolds cellularized with smooth muscle cells.听Biotechnol J聽1700768.听

Kumra H, Reinhardt DP. (2018). Fibrillins.听Methods Cell Biol聽143: 223-246.听

Kumra H, Sabatier L, Hassan A, Sakai T, Mosher DF, Brinckmann J, Reinhardt DP. (2018). Roles of fibronectin isoforms in neonatal vascular development and matrix integrity.听PLoS Biol聽16: e2004812.听

Lee K-WL, Gade PS, Dong L, Zhang Z, Mubin Aral A, Jin G, Ding X, Stowell CET, Umer Nisar M, Kim K, Reinhardt DP, Solari MG, Gorantla VS, Robertson AM, Wang Y. (2018). A biodegradable synthetic graft for small arteries matches the performance of autologous vein in rat carotid arteries.听Biomaterials聽181: 67-80.听

Pezzoli D, Di Paolo J, Kumra H, Fois G, Candiani G, **Reinhardt DP, **Mantovani D, **Co-corresponding authors contributed equally to this work. (2018). Fibronectin promotes elastin deposition, elasticity and mechanical strength in cellularised collagen-based scaffolds.听Biomaterials聽180: 130-142.听

Regalado ES, Mellor-Crummey L, De Backer J, Braverman AC, Ades L, Benedict S, Bradley TJ, Brickner ME, Chatfield KC, Child A, Feist C, Holmes KW, Iannucci G, Lorenz B, Mark P, Morisaki T, Morisaki H, Morris SA, Mitchell AL, Ostergaard JR, Richer J, Sallee D, Shalhub S, Tekin M, Montalcino Aortic Consortium**, Estrera A, Musolino P, Yetman A, Pyeritz R, Milewicz DM, **Reinhardt DP is member of this consortium. (2018). Clinical history and management recommendations of the smooth muscle dysfunction syndrome due to ACTA2 arginine 179 alterations.听Genet Med聽20: 1206-1215.听

Gilpin SE, Li Q, Evangelista-Leite D, Ren X, Reinhardt DP, Frey BL, Ott HC. (2017). Fibrillin-2 and Tenascin-C bridge the age gap in lung epithelial regeneration.听Biomaterials聽140: 212-219.听

Hubmacher D, Schneider M, Berardinelli SJ, Takeuchi H, Willard B, Reinhardt DP, Haltiwanger RS, Apte SS. (2017). Unusual life cycle and impact on microfibril assembly of ADAMTS17, a secreted metalloprotease mutated in genetic eye disease.听Sci Rep聽7: 41871.听

Lee CS, Fu H, Baratang N, Rousseau J, Kumra H, Sutton VR, Niceta M, Ciolfi A, Yamamoto G, Bertola D, Marcelis CL, Lugtenberg D, Bartuli A, Kim C, Hoover-Fong J, Sobreira N, Pauli R, Bacino C, Krakow D, Parboosingh J, Yap P, Kariminejad A, McDonald MT, Aracena MI, Lausch E, Unger S, Superti-Furga A, Lu JT, Baylor-Hopkins Center for Mendelian Genomics, Cohn DH, Tartaglia M, Lee BH, **Reinhardt DP, **Campeau PM, **Co-corresponding authors contributed equally to this work. (2017). Mutations in fibronectin cause a subtype of spondylometaphyseal dysplasia with 鈥渃orner fractures鈥�.听Am J Hum Genet聽101: 815-823.听

Zeyer KA, Reinhardt DP. (2017). Fibrillin-1 in connective tissues.听滨苍:听Marfan Syndrome. Eds. Marfan Hilfe e. V. Springer, Berlin (Germany). Chp. 13, 64-66.听

Jondeau G, Ropers J, Regalado E, Braverman A, Evangelista A, Teixedo G, De Backer J, Muino-Mosquera L, Naudion S, Zordan C, Morisaki H, Morisaki Y, von Kodolitsch Y, Dupuis-Girod S, Morris SA, Jeremy R, Odent S, Ades LC, Bakshi M, Holman K, LeMaire S, Milleron O, Langeois M, Spentchian M, Aubart M, Boileau C, Pyeritz R, Milewicz DM, Montalcino Aortic Consortium**, **Reinhardt DP is member of this consortium. (2016). International Registry of Patients Carrying TGFBR1 or TGFBR2 Mutations: Results of the Montalcino Aortic Consortium.听Circ Cardiovasc Genet聽9: 548-558.听

Kahle B, Schmidtke C, Hunzelmann N, Bartels C, Sievers HH, Reinhardt DP, Brinckmann J. (2016). The extracellular matrix signature in vein graft disease.听Can J Cardiol聽32: 1008.e11-7.听

Kumra H, Reinhardt DP. (2016). Fibronectin-targeted drug delivery in cancer.听Adv Drug Deliv Rev聽97: 101-110.听

Li CD, Hancock MA, Seghal P, Zhou S, Reinhardt DP, Philip A. (2016). Soluble CD109 binds TGF-脽 and antagonizes TGF-脽 signaling and responses.听Biochem J聽473: 537-547.听

Loy C, Meghezi S, L茅vesque L, Pezzoli D, Kumra H, Reinhardt DP, Kizhakkedathu JN, Mantovani D. (2016). A planar model of the vessel wall from cellularized collagen scaffolds: focus on cell鈥搈atrix interactions in mono-, bi- and tri-culture models.听Biomater Sci聽5: 153-162.听

Schaefer L, Reinhardt DP. (2016). Extracellular matrix: Therapeutic tools and targets in cancer treatment.听Adv Drug Deliv Rev聽97: 1-3.听

Guo DC, Gong L, Regalado ES, Santos-Cortez RL, Zhao R, Cai B, Veeraraghavan S, Prakash SK, Johnson RJ, Muilenburg A, Willing M, Jondeau G, Boileau C, Pannu H, Moran R, Debacker J, GenTac Investigators National Heart Lung Blood Institute Go Exome Sequencing Project, Montalcino Aortic Consortium**, Bamshad MJ, Shendure J, Nickerson DA, Leal SM, Raman CS, Swindell EC, Milewicz DM, **Reinhardt DP is member of this consortium. (2015). MAT2A mutations predispose individuals to thoracic aortic aneurysms.听Am J Hum Genet聽96: 170-177.听

Hinderer S, Shena N, Ringuette LJ, Hansmann J, Reinhardt DP, Brucker SY, Davis EC, Schenke-Layland K. (2015). In vitro elastogenesis - Instructing human vascular smooth muscle cells to generate an elastic fiber-containing extracellular matrix scaffold.听Biomed Mater聽10: 034102.听

Hubmacher D, Wang LW, Mecham RP, Reinhardt DP, Apte SS. (2015). Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia: A novel mouse model providing insights on geleophysic dysplasia.听Dis Model Mech聽8: 487-499.听

Kaur J, Reinhardt DP. (2015). Extracellular Matrix Molecules.听滨苍:听Stem Cell Biology and Tissue Engineering in Dental Science. Eds. Vishwakarma A, Sharpe PT, Shi S, Wang X, Ramalingam M. Elsevier, New York. Chp. 3, 25-43.听

Regalado ES, Guo DC, Prakash S, Bensend TA, Flynn K, Estrera A, Safi H, Liang D, Hyland J, Child A, Arno G, Boileau C, Jondeau G, Braverman A, Moran R, Morisaki T, Morisaki H, Montalcino Aortic Consortium**, Pyeritz R, Coselli J, LeMaire S, Milewicz DM, **Reinhardt DP is member of this consortium. (2015). Aortic disease presentation and outcome associated with ACTA2 mutations.听Circ Cardiovasc Genet聽8: 457-464.听

Zeyer KA, Reinhardt DP. (2015). Fibrillin-containing microfibrils are key signal relay stations for cell function.听J Cell Commun Signal聽9: 309-325.听

Zeyer KA, Reinhardt DP. (2015). Engineered mutations in fibrillin-1 leading to Marfan syndrome act at the protein and cellular levels.听Mutat Res Rev聽765: 7-18.听

Hubmacher D, Bergeron E, Fagotto-Kaufmann C, Sakai LY, Reinhardt DP. (2014). Early fibrillin-1 assembly monitored through a modifiable recombinant cell approach.听Biomacromolecules聽15: 1456-1468.听

Hubmacher D, Reinhardt DP, Plesec T, Schenke-Layland K, Apte SS. (2014). Human eye development is characterized by coordinated expression of fibrillin isoforms.听Invest Ophthalmol Vis Sci聽55: 7934-7944.听

Marek I, Volkert G, Hilgers KF, Bieritz B, Rascher W, Reinhardt DP, Hartner A. (2014). Fibrillin-1 and alpha8 integrin are co-expressed in the glomerulus and interact to convey firm adhesion of mesangial cells.听Cell Adh Migr聽8: 389-395.听

Muiznieks LD, Cirulis JT, van der Horst A, Reinhardt DP, Wuite GJL, Pom猫s R, Keeley FW. (2014). Modulated growth, stability and interactions of liquid-like coacervate assemblies of elastin.听Matrix Biol聽36: 39-50.听

Murphy EC, M枚rgelin M, Reinhardt DP, Bj枚rck L, Frick IM. (2014). Finegoldia magna uses its cell surface and extracellular proteins, FAF and SufA, to colonise and pass into deeper fractions of human skin.听Mol Microbiol聽94: 403-417.听

Reinhardt DP. (2014). Microfibril-associated disorders: fibrillinopathies.听J Glaucoma聽23: S34-S35.听

Sabatier L, Djokic J, Hubmacher D, Dzafik D, Nelea V, Reinhardt DP. (2014). Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.听FEBS Lett聽588: 2890-2897.听

Beene LC, Wang LW, Hubmacher D, Keene DR, Reinhardt DP, Annis DS, Mosher DF, Mecham RP, Traboulsi EI, Apte SS. (2013). Non-selective assembly of fibrillin-1 and fibrillin-2 in the rodent ocular zonule and in cultured cells: Implications for Marfan syndrome.听Invest Ophthalmol Vis Sci聽54: 8337-8344.听

Djokic J, Fagotto-Kaufmann C, Bartels R, Nelea V, Reinhardt DP. (2013). Fibulin-3, -4, and -5 are highly susceptible to proteolysis, interact with cells and heparin, and form multimers.听J Biol Chem聽288: 22821-22835.听

Hummitzsch K, Irving-Rodgers HF, Hatzirodos N, Bonner W, Sabatier L, Reinhardt DP, Sado Y, Ninomiya Y, Wilhelm D, Rodgers RJ. (2013). A new model of development of the mammalian ovary and follicles.听PLoS One聽8: e55578.听

Sabatier L, Djokic J, Fagotto-Kaufmann C, Chen M, Annis DS, Mosher DF, Reinhardt DP. (2013). Complex contributions of fibronectin to initiation and maturation of microfibrils.听Biochem J聽456: 283-295.听

Tiedemann K, Boraschi-Diaz I, Rajakumar I, Kaur J, Roughley P, **Reinhardt DP, **Komarova SV, **Co-senior authors contributed equally to this work. (2013). Fibrillin-1 directly regulates osteoclast formation and function by a dual mechanism.听J Cell Sci聽126: 4187-4194.听

Votteler M, Carvaja Berrio DA, Horke A, Sabatier L, Reinhardt DP, Nsair A, Aikawa E, Schenke-Layland K. (2013). Elastogenesis at the onset of human cardiac valve development.听Development聽140: 2345-2353.听

Bader HL, Wang LW, Ho J, Tran T, Holden P, Fitzgerald J, Atit RP, Reinhardt DP, Apte SS. (2012). A disintegrin-like and metalloprotease domain containing thrombospondin type 1 motif-like 5 (ADAMTSL5) is a novel fibrillin-1-, fibrillin-2-, and heparin-binding member of the ADAMTS superfamily containing a netrin-like module.听Matrix Biol聽31: 398-411.听

Kaur J, Reinhardt DP. (2012). Immobilized metal affinity chromatography co-purifies TGF-beta1 with histidine-tagged recombinant extracellular proteins.听PLoS One聽7: e48629.听

Lammers G, Roth G, Heck M, Zengerle R, Tjabringa GS, Versteeg EM, Hafmans T, Wismans R, Reinhardt DP, Verwiel ET, Verwiel E, Zeeuwen PL, Schalkwijk J, Brock R, Daamen WF, van Kuppevelt TH. (2012). Construction of a microstructured collagen membrane mimicking the papillary dermis architecture and guiding keratinocyte morphology and gene expression.听Macromol Biosci聽12: 675-691.听

Piha-Gossack A, Sossin W, Reinhardt DP. (2012). The evolution of extracellular fibrillins and their functional domains.听PLoS One聽7: e33560.听

Hatzirodos N, Bayne RA, Irving-Rodgers HF, Hummitzsch K, Sabatier L, Lee S, Bonner W, Gibson MA, Rainey WE, Carr BR, Mason HD, Reinhardt DP, Anderson RA, Rodgers R. (2011). Linkage of regulators of TGF-beta activity in the fetal ovary to polycystic ovary syndrome.听FASEB J聽25: 2256-2265.听

Hubmacher D, Reinhardt DP. (2011). Microfibrils and fibrillin.听滨苍:听The Extracellular Matrix: an Overview. Eds. Mecham RP. Springer, Berlin. Chp. 7, 233-265.听

Hubmacher D, Sabatier L, Annis DS, Mosher DF, Reinhardt DP. (2011). Homocysteine modifies structural and functional properties of fibronectin and interferes with the fibronectin-fibrillin-1 interaction.听Biochemistry聽50: 5322-5332.听

Kirschner R, Hubmacher D, Iyengar G, Kaur J, Fagotto-Kaufmann C, Bromme D, Bartels R, Reinhardt DP. (2011). Classical and neonatal Marfan syndrome mutations in fibrillin-1 cause differential protease susceptibilities and protein function.听J Biol Chem聽286: 32810-32823.听

Sabatier L, Miosge N, Hubmacher D, Lin G, Davis EC, Reinhardt DP. (2011). Fibrillin-3 expression in human development.听Matrix Biol聽30: 43-52.听

Brinckmann J, Hunzelmann N, Kahle B, Rohwedel J, Kramer J, Hubmacher D, Reinhardt DP. (2010). Enhanced fibrillin-2 expression is a general feature of wound healing and sclerosis: Potential alteration of cell attachment and storage of TGF-beta.听Lab Invest聽90: 739-752.听

Hubmacher D, Cirulis JT, Miao M, Keeley FW, Reinhardt DP. (2010). Functional consequences of homocysteinylation of the elastic fiber proteins fibrillin-1 and tropoelastin.听J Biol Chem聽285: 1188-1198.听

Schenke-Layland K, Xie J, Magnusson M, Angelis E, Li X, Wu K, Reinhardt DP, MacLellan WR, Hamm-Alvarez SF. (2010). Lymphocytic infiltration leads to degradation of lacrimal gland extracellular matrix structures in NOD mice exhibiting a Sj枚gren's syndrome-like exocrinopathy.听Exp Eye Res聽90: 223-237.听

Hubmacher D, Reinhardt DP. (2009). One more piece in the fibrillin puzzle.听Structure聽7: 635-636.听

Koenders MMJF, Yang L, Wismans RG, van der Werf KO, Reinhardt DP, Daamen W, Bennink ML, Dijkstra PJ, van Kuppevelt TH, Feijen J. (2009). Microscale mechanical properties of single elastic fibers: The role of fibrillin-microfibrils.听Biomaterials聽30: 2425-2432.听

Sabatier L, Chen D, Fagotto-Kaufmann C, Hubmacher D, McKee MD, Annis DS, Mosher DF, Reinhardt DP. (2009). Fibrillin assembly requires fibronectin.听Mol Biol Cell聽20: 846-858.听

Sabatier L, Chen D, Fagotto-Kaufmann C, Hubmacher D, McKee MD, Annis DS, Mosher DF, Reinhardt DP. (2009). Fibrillin assembly requires fibronectin - Incytes Highlight.听Mol Biol Cell聽20: 1119-1119.听

Cirulis JT, Bellingham CM, Davis EC, Hubmacher D, Reinhardt DP, Mecham RP, Keeley FW. (2008). Fibrillins, fibulins and MAGP modulate the kinetics and morphology of in vitro self-assembly of a recombinant elastin-like polypeptide.听Biochemistry聽47: 12601-12613.听

Daamen WF, Nillesen STM, Wismans R, Reinhardt DP, Hafmans T, Veerkamp JH, van Kuppevelt T. (2008). A biomaterial composed of collagen and solubilised elastin enhances angiogenesis and elastic fibre formation without calcification.听Tissue Eng聽14: 349-360.听

Fricke M, Langer C, Brunner E, Sakai LY, F眉zesi L, Reinhardt DP, Quondamatteo F. (2008). Fibrillin-1 in incisional hernias. An immunohistochemical study in scar and non-scar regions of human skin and muscle fasciae.听J Anat聽212: 674-685.听

Hubmacher D, El-Hallous EI, Nelea V, Kaartinen MT, Lee ER, Reinhardt DP. (2008). Biogenesis of extracellular microfibrils-Multimerization of the fibrillin-1 C-terminus into bead-like structures enables self-assembly.听Proc Natl Acad Sci U S A聽105: 6548-6553.听

Kloepper JE, Tiede S, Brinckmann J, Reinhardt DP, F盲ssler R, Paus R. (2008). Immunophenotyping of the human bulge region: The quest to define useful in situ markers for human epithelial hair follicle stem cells and their niche.听Exp Dermatol聽17: 592-609.听

Wilkinson GA, Schittny JC, Reinhardt DP, Klein R. (2008). Role for ephrinB2 in postnatal lung alveolar development and elastic matrix integrity.听Dev Dyn聽237: 2220-2234.听

El-Hallous EI, Sasaki T, Hubmacher D, Getie M, Tiedemann K, Brinckmann J, B盲tge B, Davis EC, Reinhardt DP. (2007). Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adapter function to tropoelastin.听J Biol Chem聽282: 8935-8946.听

Gnainsky Y, Kushnirsky Z, Bilu G, Hagai Y, Genina O, Volpin H, Bruck R, Spira G, Nagler A, Kawada N, Yoshizato K, Reinhardt DP, Libermann TA, Pines M. (2007). Gene expression during chemically induced liver fibrosis - effect of halofuginone on TGF-beta signaling.听Cell Tissue Res聽328: 153-166.听

Schaefer L, Tsalastra W, Babelova A, Baliova M, Minnerup J, Sorokin L, Gr枚ne HJ, Reinhardt DP, Pfeilschifter J, Iozzo RV, Schaefer RM. (2007). Decorin-mediated regulation of fibrillin-1 in the kidney involves the IGF-I receptor and mTOR.听Am J Pathol聽170: 301-315.听

Drumea-Mirancea M, Wessels JT, M眉ller CA, Essl M, Eble JA, Tolosa M, Koch M, Reinhardt DP, Sixt M, Sorokin L, Stierhof YD, Schwarz H, Klein G. (2006). Characterization of a laminin-5 containing conduit system in the human thymus - a transport system for small molecules.听J Cell Sci聽119: 1396-1405.听

Hartner A, Schaefer L, Porst M, Cordasic N, Gabriel A, Klanke B, Reinhardt DP, Hilgers KF. (2006). Role of fibrillin-1 in hypertensive and diabetic glomerular disease.听American Journal of Physiology: Renal Physiology聽290: F1329-F1336.听

Hubmacher D, Tiedemann K, Reinhardt DP. (2006). Fibrillins: From biogenesis of microfibrils to signaling functions.听Curr Top Dev Biol聽75: 93-123.听

Porst M, Daniel C, Plank C, Schocklmann HO, Reinhardt DP, Hartner A. (2006). Induction and coexpression of latent transforming growth factor beta-binding protein 1 (LTBP-1) and fibrillin-1 in experimental glomerulonephritis.听Nephron Exp Nephrol聽102: e99-e104.听

Porst M, Plank C, Bieritz B, Konik E, Fees H, D枚tsch J, Hilgers KF, Reinhardt DP, Hartner A. (2006). Fibrillin-1 regulates mesangial cell attachment, spreading, migration and proliferation.听Kidney Int聽69: 450-456.听

Reinhardt DP. (2006). Connective Tissue.听滨苍:听Marfan-Syndrom - Ein Ratgeber f眉r Patienten, Angeh枚rige und Betreuende. Eds. Marfan Hilfe e. V. Steinkopff Verlag, Darmstadt (Germany). Chp. 6, 26-33.听

Robinson P, Arteaga-Solis E, Baldock C, Collod-Beroud G, Booms P, De Paepe A, Dietz HC, Guo G, Handford PA, Judge DP, Kielty CM, Loeys B, Milewicz DM, Ney A, Ramirez F, Reinhardt DP, Tiedemann K, Whiteman P, Godfrey M. (2006). The molecular genetics of Marfan syndrome and related disorders.听J Med Genet聽43: 769-787.听

Robinson PN, Reinhardt DP. (2006). Research Outlook.听滨苍:听Marfan-Syndrom - Ein Ratgeber f眉r Patienten, Angeh枚rige und Betreuende. Eds. Marfan Hilfe e. V. Steinkopff Verlag, Darmstadt (Germany). Chp. 19, 143-148.听

Wu J, Reinhardt DP, Batmunkh C, Lindenmaier W, Kretschmer-Kazemi Far R, Notbohm H, Hunzelmann N, Brinckmann J. (2006). Functional diversity of lysyl hydroxylase 2 in collagen synthesis of human dermal fibroblasts.听Exp Cell Res聽312: 3485-3494.听

Booms P, Pregla R, Ney A, Barthel F, Reinhardt DP, Pletschacher A, Mundlos S, Robinson PN. (2005). RGD-containing fibrillin-1 fragments upregulate matrix metalloproteinase expression in cell culture: A potential factor in the pathogenesis of the Marfan syndrome.听Hum Genet聽116: 51-61.听

Bouzeghrane F, Reinhardt DP, Reudelhuber T, Thibault G. (2005). Enhanced expression of fibrillin-1, a constituent of the myocardial extracellular matrix, in fibrosis.听American Journal of Physiology: Heart and Circulatory Physiology聽289: H982-H991.听

Brinckmann J, Hunzelmann N, El-Hallous EI, Krieg T, Sakai LY, Krengel S, Reinhardt DP. (2005). Absence of autoantibodies against correctly folded recombinant fibrillin-1 protein in systemic scleroderma patients.听Arthritis Res Ther聽7: R1221-R1226.听

Brinckmann J, Kim S, Wu J, Reinhardt DP, Batmunkh C, Metzen E, Notbohm H, Bank RA, Krieg T, Hunzelmann N. (2005). Interleukin 4 and prolonged hypoxia induce a higher gene expression of lysyl hydroxylase 2 and an altered cross-link pattern: Important pathogenetic steps in early and late stage of systemic scleroderma?聽Matrix Biol聽24: 459-468.听

Hubmacher D, Tiedemann K, Bartels R, Brinckmann J, Vollbrandt T, B盲tge B, Notbohm H, Reinhardt DP. (2005). Modification of the structure and function of fibrillin-1 by homocysteine suggests a potential pathogenetic mechanism in homocystinuria.听J Biol Chem聽280: 34946-34955.听

Sixt M, Kanazawa N, Selg M, Samson T, Roos G, Reinhardt DP, Pabst R, Lutz MB, Sorokin L. (2005). The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node.听Immunity聽22: 19-29.听

Tiedemann K, Sasaki T, Gustafsson E, G枚hring W, B盲tge B, Notbohm H, Timpl R, Wedel T, Schl枚tzer-Schrehardt U, Reinhardt DP. (2005). Microfibrils at basement membrane zones interact with perlecan via fibrillin-1.听J Biol Chem聽280: 11404-11412.听

Gaber Y, Tiedemann K, Reinhardt DP, Brinckmann J. (2004). Changes in crosslinks in the collagenous connective tissue of lipodermatosclerosis.听Phlebologie聽33: 8-11.听

Hartner A, Eifert T, Haas CS, Tuysuz C, Hilgers KF, Reinhardt DP, Amann K. (2004). Characterization of the renal phenotype in a mouse model of Marfan Syndrome.听Virchows Arch聽445: 382-388.听

Kassner A, Tiedemann K, Notbohm H, Ludwig T, M枚rgelin M, Reinhardt DP, Chu ML, Bruckner P, Gr盲ssel S. (2004). Molecular structure and interaction of recombinant human type XVI collagen.听J Mol Biol聽339: 835-853.听

Lorena D, Darby IA, Reinhardt DP, Sapin V, Rosenbaum J, Desmouliere A. (2004). Fibrillin-1 expression in normal and fibrotic rat liver and in cultured hepatic fibroblastic cells: Modulation by mechanical stress and role in cell adhesion.听Lab Invest聽84: 203-212.听

Schaefer L, Mihalik D, Babelova A, Krzyzankova M, Grone HJ, Iozzo RV, Young MF, Seidler DG, Lin G, Reinhardt DP, Schaefer RM. (2004). Regulation of fibrillin-1 by biglycan and decorin is important for tissue preservation in the kidney during pressure-induced injury.听Am J Pathol聽165: 383-396.听

Tiedemann K, B盲tge B, Reinhardt DP. (2004). Assembly of microfibrils.听滨苍:听Marfan Syndrome: A Primer for Clinicians and Scientists. Eds. Robinson PN, Godfrey M. Landes Bioscience, Georgetown, Texas, USA. Chp., 130-142.听

Vollbrandt T, Tiedemann K, El-Hallous EI, Lin G, Brinckmann J, John H, B盲tge B, Notbohm H, Reinhardt DP. (2004). Consequences of cysteine mutations in calcium-binding epidermal growth factor modules of fibrillin-1.听J Biol Chem聽279: 32924-32931.听

Charbonneau NL, Dzamba BJ, Ono RN, Keene DR, Corson GM, Reinhardt DP, Sakai LY. (2003). Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences.听J Biol Chem聽278: 2740-2749.听

Eisenbeiss C, Martinez A, Hagedorn-Greiwe M, Reinhardt DP, B盲tge B, Brinckmann J. (2003). Reduced skin thickness - a "new" minor symptom of the classical and hypermobile type of Ehlers-Danlos syndrome.听Br J Dermatol聽149: 850-852.听

Isogai Z, Ono RN, Ushiro S, Keene DR, Chen Y, Mazzieri R, Charbonneau NL, Reinhardt DP, Rifkin DB, Sakai LY. (2003). Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein.听J Biol Chem聽278: 2750-2757.听

Kassner A, Hansen U, Miosge N, Reinhardt DP, Aigner T, Bruckner-Tuderman L, Bruckner P, Gr盲ssel S. (2003). Discrete integration of collagen XVI into tissue-specific collagen fibrils or beaded microfibrils.听Matrix Biol聽22: 131-143.听

Tiedemann K, B盲tge B, Reinhardt DP. (2003). Marfan-Syndrom: Eine genetische Erkrankung des mikrofibrill盲ren Systems.听Bioforum聽7-8: 456-457.听

Isogai Z, Aspberg A, Keene DR, Ono RN, Reinhardt DP, Sakai LY. (2002). Versican interacts with fibrillin-1 and links extracellular microfibrils to other connective tissue networks.听J Biol Chem聽277: 4565-4572.听

Lin G, Tiedemann K, Vollbrandt T, Peters H, B盲tge B, Brinckmann J, Reinhardt DP. (2002). Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.听J Biol Chem聽277: 50795-50804.听

Piecha D, Wiberg C, M枚rgelin M, Reinhardt DP, Deak F, Maurer P, Paulsson M. (2002). Matrilin-2 interacts with itself and with other extracellular matrix proteins.听Biochem J聽367: 715-721.听

Quondamatteo F, Reinhardt DP, Charbonneau NL, Pophal G, Sakai LY, Herken R. (2002). Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development.听Matrix Biol聽21: 637-646.听

Areida SK, Reinhardt DP, M眉ller PK, Fietzek PP, K枚witz J, Marinkovich MP, Notbohm H. (2001). Properties of the collagen type XVII ectodomain. Evidence for N- to C-terminal triple helix folding.听J Biol Chem聽276: 1594-1601.听

Jensen SA, Reinhardt DP, Gibson MA, Weiss AS. (2001). MAGP-1, Protein interaction studies with tropoelastin and fibrillin-1.听J Biol Chem聽276: 39661-39666.听

Tiedemann K, B盲tge B, M眉ller PK, Reinhardt DP. (2001). Interactions of fibrillin-1 with heparin/heparan sulfate: Implications for microfibrillar assembly.听J Biol Chem聽276: 36035-36042.听

Winkler J, Wirbelauer C, L眉nsdorf H, Reinhardt DP, Laqua H. (2001). Immunohistochemical and charge-specific localization of anionic components of aggregates on the central anterior lens capsules from individuals with Pseudoexfoliation syndrome.听Graefes Arch Clin Exp Ophthalmol聽239: 952-960.听

Handford PA, Downing AK, Reinhardt DP, Sakai LY. (2000). Fibrillin: from domain structure to supramolecular assembly.听Matrix Biol聽19: 457-470.听

Reinhardt DP, Gambee JE, Ono RN, B盲chinger HP, Sakai LY. (2000). Initial steps in assembly of microfibrils. Formation of disulfide-cross-linked multimers containing fibrillin-1.听J Biol Chem聽275: 2205-2210.听

Reinhardt DP, Ono RN, Notbohm H, M眉ller PK, B盲chinger HP, Sakai LY. (2000). Mutations in calcium-binding epidermal growth factor modules render fibrillin-1 susceptible to proteolysis: A potential disease-causing mechanism in Marfan syndrome.听J Biol Chem聽275: 12339-12345.听

Wirbelauer C, Reinhardt DP, L眉nsdorf H, Weber E, Laqua H, Winkler J. (2000). Charakterisierung der extrazellul盲ren Matrix beim Pseudoexfoliationssyndrom.听Focus MUL聽17: 82-87.听

L枚nnqvist L, Reinhardt DP, Sakai LY, Peltonen L. (1998). Evidence for furin-type activity-mediated C-terminal processing of profibrillin-1 and interference in the processing by certain mutations.听Hum Mol Genet聽7: 2039-2044.听

Keene DR, Jordan CD, Reinhardt DP, Ridgway CC, Ono RN, Corson GM, Fairhurst M, Sussman MD, Memoli VA, Sakai LY. (1997). Fibrillin-1 in human cartilage: developmental expression and formation of special banded fibers.听J Histochem Cytochem聽45: 1069-1082.听

Pereira L, Andrikopoulos K, Tian J, Lee SY, Keene DR, Ono RN, Reinhardt DP, Sakai LY, Jensen-Biery N, Bunton T, Dietz HC, Ramirez F. (1997). Targeting of fibrillin-1 recapitulates the vascular phenotype of Marfan syndrome in the mouse.听Nat Genet聽17: 218-222.听

Reinhardt DP, Mechling DE, Boswell BA, Keene DR, Sakai LY, B盲chinger HP. (1997). Calcium determines the shape of fibrillin.听J Biol Chem聽272: 7368-7373.听

Reinhardt DP, Ono RN, Sakai LY. (1997). Calcium stabilizes fibrillin-1 against proteolytic degradation.听J Biol Chem聽272: 1231-1236.听

Pfaff M, Reinhardt DP, Sakai LY, Timpl R. (1996). Cell adhesion and integrin binding to recombinant human fibrillin-1.听FEBS Lett聽384: 247-250.听

Reinhardt DP, Keene DR, Corson GM, P枚schl E, B盲chinger HP, Gambee JE, Sakai LY. (1996). Fibrillin 1: organization in microfibrils and structural properties.听J Mol Biol聽258: 104-116.听

Reinhardt DP, Sasaki T, Dzamba BJ, Keene DR, Chu ML, G枚hring W, Timpl R, Sakai LY. (1996). Fibrillin-1 and fibulin-2 interact and are colocalized in some tissues.听J Biol Chem聽271: 19489-19496.听

Mayer U, Zimmermann K, Mann K, Reinhardt DP, Timpl R, Nischt R. (1995). Binding properties and protease stability of recombinant human nidogen.听Eur J Biochem聽227: 681-686.听

Reinhardt DP, Chalberg SC, Sakai LY. (1995). The structure and function of fibrillin.听滨苍:听The molecular biology and pathology of elastic tissues. Eds. John Wiley and Sons, Chichester, England. Chp., 128-147.听

Aumailley M, Battaglia C, Mayer U, Reinhardt DP, Nischt R, Timpl R, Fox JW. (1993). Nidogen mediates the formation of ternary complexes of basement membrane components.听Kidney Int聽43: 7-12.听

Reinhardt DP, Mann K, Nischt R, Fox JW, Chu ML, Krieg T, Timpl R. (1993). Mapping of nidogen binding sites for collagen type IV, heparan sulfate proteoglycan, and zinc.听J Biol Chem聽268: 10881-10887.听

K眉bler D, Reinhardt DP, Reed J, Pyerin W, Kinzel V. (1992). Atrial natriuretic peptide is phosphorylated by intact cells through cAMP-dependent ecto-protein kinase.听Eur J Biochem聽206: 179-186.听

Fox JW, Mayer U, Nischt R, Aumailley M, Reinhardt DP, Wiedemann H, Mann K, Timpl R, Krieg T, Engel J, Chu ML. (1991). Recombinant nidogen consists of three globular domains and mediates binding of laminin to collagen type IV.听EMBO J聽10: 3137-3146.听