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Wayne Sossin, PhD

Wayne Sossin, PhD
Contact Information
Phone: 
514-398-1486
Fax number: 
514-398-8106
Email address: 
wayne.sossin [at] mcgill.ca
Hospital title: 
Distinguished James McGill Professor
Biography: 

Wayne Sossin is interested in the specialized cellular and molecular events that shape brain function. Sossin Ìýis interested in neurodevelopmental disorders and the role that local protein synthesis in neurons plays in the origin and regulation of these disorders.  In particular, the lab examines how neurons transport mÏ㽶ÊÓƵs to synapses as stalled ribosomes. Sossin has proposed that memories are stored using specialized synapses that can be distinguished by their molecular constituents. This proposal is being examined both in the simple nervous system of Aplysia, where behavioural memory is encoded by changes in the synaptic strength of identified neurons and in rodent models where powerful genetic tools allows for detailed correlations between molecular changes and behavior. Ìý

Selected publications: 

Anadolu M, Sun J, Li JT, Graber TE, Ortega J, Sossin WS. (2024) Puromycin reveals a distinct conformation of neuronal ribosomes (PNAS, Feb 13;121(7):e2306993121. doi: 10.1073/pnas.2306993121.Ìý

ÌýZha C, Farah CA, Holt RJ, Ceroni F, AlAbdi L, Thuriot F, Khan AO, Helaby R, Lévesque S, Alkuraya FS, Kraus A, Ragge N, Sossin WS. (2020)Biallelic variants in the small optic lobe calpain CAPN15 are associated with congenital eye anomalies, deafness and other neurodevelopmental deficits. Hum. Mol. Genet. 29: 3054-3063  Ìý

Ferguson L, Hu J, Cai D, Chen S, Dunn TW, Pearce K, Glanzman DL, Schacher S, Sossin WS. (2019) J. Neuroscience Oct 30;39(44):8632-8644. doi: 10.1523/JNEUROSCI.0943-19.2019. Epub 2019 Sep 19.Sossin WS and Costa-Mattioli M (2018) Translational Control in the Brain in Health and Disease. Cold Spring Harbor Perspectives in Biology doi: 10.1101/cshperspect.a032912 Ìý

Sossin WS (2018) Memory synapses are distinguished by distinct molecular complexes: A proposal. Frontiers in Synaptic Neuroscience doi: 10.3389/fnsyn.2018.00005. Ìý

Research areas: 
Neurodevelopmental Disorders

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The Neuro (Montreal Neurological Institute-Hospital)Ìýis a bilingual academic healthcare institution. We are aÌýMcGill research and teaching institute; delivering high-quality patient care, as part of the Neuroscience Mission of the Ï㽶ÊÓƵ Health Centre.ÌýWe areÌýproud to be a Killam Institution, supported by the Killam Trusts.

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