Killam Seminar Series: Mechanisms and Roles of Fast Dopamine Signaling
The Killam Seminar Series presentsÌýMechanisms and Roles of Fast Dopamine Signaling.
Registration available .
³§±è±ð²¹°ì±ð°ù:ÌýPascal S. Kaeser, MD
Professor, Department of Neurobiology, Harvard Medical School, Boston, USA
´¡²ú²õ³Ù°ù²¹³¦³Ù:ÌýDopamine is a neuromodulator that codes information on various time scales. I will discuss recent progress on the identification of fast release mechanisms for dopamine in the mouse striatum. I willÌýpresent data on triggering mechanisms of dopamine release and evaluate its roles in striatal regulation. In the long-term, our work will allow for a better understanding of the mechanisms and timeÌýscales of dopamine coding in health and disease.
µþ¾±´Ç:ÌýPascal Kaeser is a native of Switzerland. He obtained his MD degree at theÌýUniversity of Zurich. In the laboratory of Dr. Adriano Aguzzi, he studied how infectious prions invade the central nervous system during transmissible spongiform encephalopathies. His research on molecular mechanisms at the synapse started with his postdoctoral training in the Laboratory of Dr. Thomas Südhof at the University of Texas Southwestern Medical Center and at Stanford University. As a fellow, Pascal discovered mechanisms through which primed synaptic vesicles are coupled to presynaptic calcium channels at sites of exocytosis called active zones. In his own laboratory in the Department of Neurobiology atÌýHarvard Medical School, Pascal studies how active zones are assembled and how they control neurotransmitter release.
Supported by the generosity of the Killam Trusts , The Neuro’s Killam Seminar series hosts outstanding guest speakers.