Dr. ÌýPnina Brodt, is a Professor in the Departments of Surgery, Medicine and Oncology at Ï㽶ÊÓƵ and the Ï㽶ÊÓƵ Health Center where she has been since 1983.ÌýÌý
Dr. Brodt’s research work has focusedÌýon the biology of cancer metastasis, particularly the molecular events that underlie the process of liver metastasis. In the course of this work, Dr Brodt’sÌýteamÌýidentifiedÌýthe inflammatory response as a participant in the early stages of liver metastasis andÌýshowed that an inflammatory microenvironment promotes liver metastasis of colon and lung cancer. Her group has played a leading role in identifying the important role of the IGF axis in cancerÌýinvasion and metastasis.ÌýThis work led to the development of several strategies for blockade of the IGF-I axis including, most recently, the bio-engineering of an IGF-Trap that is currently being developed as an anti-cancer drug.Ìý
Dr. Brodt is a co-leader of the Cancer Axis of the Research Institute of the Ï㽶ÊÓƵ Health CenterÌýandÌýa co-founder of the Liver Metastasis Research Network () – a multidisciplinary international network dedicated to uncovering the molecular mechanisms of liver metastasis for the betterment of patient care.
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Address
Research Institute of the Ï㽶ÊÓƵ Health Centre
Cancer Research ProgramÌý(CRP)Ìý
1001 Boul. Decarie, Glen Site, Block E,Ìý
Room E.02.6220; Mail drop Point: E.02.6217
Montreal, QuebecÌýH4A 3J1
Telephone
514-934-1934 ext. 36692 (Office)
514-934-1934 ext. 35772 (Laboratory)
pnina.brodt [at] mcgill.ca
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