Ï㽶ÊÓƵ

Bioengineering: Introduction to pillars of current good manufacturing practices (cGMP) in biologics, terminologies, and background; importance of cGMP for biologics manufacturing; principles of design and operation of cGMP facilities; knowledge gap between industrial processes and lab practices on GMP.

Offered by: Bioengineering

• Prerequisites: BIEN 590
• 1. Lectures from experts in the biologics manufacturing industry and translational research units in and around Canada.

• Terms
  • Fall 2024
• Instructors
  • Mario Jardon

Bioengineering: Engineering principles in biology, BioBricks and standardization of biological components, parts registries, advanced molecular biology tools for DNA assembly, genome editing, high-throughput genetic manipulation methods, construction of biological pathways, strategies for transcriptional control, examples of engineered systems.

Offered by: Bioengineering

• Restriction: Permission of instructor
• 1. (3-2-4)

• Terms
  • Winter 2025
• Instructors
  • Codruta Ignea

Bioengineering: Metabolic engineering role in transition from fossil resources to a bio-based society. Design-build-test-learn cycle of metabolic engineering. Design, genetic engineering and optimization of microbial biocatalysts. Metabolic network analysis, constraint-based modelling of metabolism, microbial production of valuable chemicals. General biochemical engineering practices. Recombinant DNA technology, enzyme function, kinetics and regulation. Cell chemistry, structure and function. Growth models, fermentation, strain development. Case studies.

Offered by: Bioengineering

• 3-2-4
• Prerequisite: Permission of the instructor.

• Terms
  • Fall 2024
• Instructors
  • Codruta Ignea

Bioengineering: Basic principles of cell culture engineering, cell line development and cell culture products; genomics, proteomics and post-translational modifications; elements of cell physiology for medium design and bioprocessing; bioreactor design, scale-up for animal cell culture and single use equipment; challenges in downstream processing of cell-culture derived products; process intensification: fed-batch, feeding strategies and continuous manufacturing; scale-down and process modeling; Process Analytical technologies and Quality by Design (QbD) concept.

Offered by: Bioengineering

• (3-0-6)
• Prerequisite: Permission of instructor.

• Terms
  • Fall 2024
  • Winter 2025
• Instructors
  • Mario Jardon
  • Mario Jardon, Amine A Kamen

Bioengineering: Fundamental and quantitative overview of Ï㽶ÊÓƵ biologics. Introduction to Ï㽶ÊÓƵ biologics associated biomanufacturing unit operations in upstream (design tools and large-scale production systems of DNA templates for in vitro Ï㽶ÊÓƵ transcription; small-scale and large-scale Ï㽶ÊÓƵ bioprocessing systems), and downstream approaches for Ï㽶ÊÓƵ purification (like Tangential flow filtration and Ï㽶ÊÓƵ-specific chromatography systems) for emerging mÏ㽶ÊÓƵ therapeutics. Introduction to established and emerging applications of Ï㽶ÊÓƵ biologics for gene and cell therapy.

Offered by: Bioengineering

• Prerequisites: BIEN 590 or permission of the instructor
• Corequisites: BIEN 670
• The course includes guest lectures from academic and industry experts in the field of Ï㽶ÊÓƵ as therapeutics for synthesis, purification, formulation and scale-up of Ï㽶ÊÓƵ biologics.

• Terms
  • Winter 2025
• Instructors
  • Ayyappasamy Sudalaiyadum Perumal

Bioengineering: Introduction to downstream processing (DSP) – principles, characteristics, purpose. Bioprocesses, biomolecules, drug substances, drug products, monoclonal antibodies and Fc fusion proteins, viral vectors, and vaccines. Unit operations - standard practices. Steps and techniques in downstream processing. Harvest and Filtration, Primary capture, Buffer exchange and up-concentration, Purification, Bioconjugation, Formulation. Optimization of downstream processing. Process Analytical Technology (PAT) to support Quality by Design (QbD) in DSP. Regulatory guidelines. Innovative Techniques for Downstream Bioprocessing.

Offered by: Bioengineering

• Prerequisites: BIEN 590 or permission of the instructor

• Terms
  • Fall 2024
• Instructors
  • Ayyappasamy Sudalaiyadum Perumal

Bioengineering: Introduction to Process Analytical Technologies (PAT) and Quality by Design (QbD) in the area of manufacturing biologics. Critical Process Parameters (CPP) and Design Space. Analytical Technologies for Biologics and Biologic Medicines and determination of Critical Quality Attributes of products. Case studies. At-line, On-line and Off-line monitoring tools, data acquisition and advanced process control strategies as applied to current industrial biomanufacturing. PAT data processing and modeling to design advanced biomanufacturing processes.

Offered by: Bioengineering

• Prerequisites: BIEN 590 or permission of the instructor.

• Terms
  • Fall 2024
• Instructors
  • Shawn Chahal, Amine A Kamen

Bioengineering: Building on recent developments and expansion in the mammalian cell culture for production of complex biologics such as viral vaccines and viral vectors, the following topics will be covered: Principles of immunology and industrial virology; Cell physiology for vaccine production; Cell lines for vaccine production; Upstream process development and process intensification strategies; Purification and downstream processing of viral vaccines; Analytical and potency assays; Formulations and delivery of vaccines; Basics of clinical trials and regulatory principles; Immunization policies. Case studies on bioprocessing/manufacturing licensed vaccines.

Offered by: Bioengineering

• Prerequisite: Permission of Instructor.

• Terms
  • Winter 2025
• Instructors
  • Mario Jardon

Bioengineering: Basic knowledge in the design and biomanufacturing of viral vectors for gene and cell therapy interventions. Practical examples and case studies highlighting challenges and solutions associated with use of viral vectors such as Adeno-Associated Vectors (AAV), lentivirus vectors and Adenovirus vectors for gene delivery. Fundamental principles of gene and cell therapies through in-vivo and ex-vivo interventions. Design of AAV, Lentivirus and Adenovirus vectors: example of targeted diseases, including CAR-T cell therapy. Technologies and modes of vector manufacturing for clinical use.

Offered by: Bioengineering

• Prerequisites: BIEN 590 or permission of the instructor
• Restrictions: Not open to students who have taken or are taking BIEN 680

• Terms
  • Winter 2025
• Instructors
  • Amine A Kamen

Biomedical Engineering: Application of the principles of engineering, physical, and biological sciences to modify and create cells and tissues for therapeutic applications will be discussed, as well as the industrial perspective and related ethical issues.

Offered by: Biomedical Engineering

• (3-0-6)
• 1.5 hours lecture/1.5 hours seminar per week
• Restriction: graduate and final year undergraduate students from physical, biological, and medical science, and engineering.

• Terms
  • Winter 2025
• Instructors
  • Satya Prakash

Biomedical Engineering: Introduction to technologies for formulation and delivery of biotherapeutics. Emphasis is placed on the fundamental principles of formulation, delivery systems, manufacturing, analytical techniques, and biomedical applications. Translational aspects are considered for formulated biotherapeutic products.

Offered by: Biomedical Engineering

• Prerequisites CHEE 380 (or equivalent), CHEM 212 (or equivalent), and BIOL 201 (or equivalent), or permission of the instructor.

• Terms
  • Fall 2024
• Instructors
  • Guojun Chen

Chemical Engineering: Introduction to stem cell biology. Cell growth models applicable to stem cells and their progeny. Upstream processing (cell culture systems, bioreactors), downstream processing (cell separation, purification) and quality management (current good manufacturing practice, regulations) applied to therapeutic cells.

Offered by: Chemical Engineering

• (3-0-6)
• Prerequisite(s): MATH 262 and CHEE 370 or BIOL 200, or Permission of Instructor.
• Restriction: Open to undergraduate and graduate students registered in Chemical Engineering, as well as graduate students registered in the McGill Graduate Certificate in Regenerative Medicine program or in the M.Eng. in Biological and Biomedical Engineering program.

• Terms
  • This course is not scheduled for the 2024 academic year
• Instructors
  • There are no professors associated with this course for the 2024 academic year

Chemical Engineering: The use of chemical engineering and biological principles in the study, design, use and creation of biologically-based processes and products. Topics: biochemical thermodynamics, protein engineering, manipulation of gene expression, transport phenomena and bioreactor design.

Offered by: Chemical Engineering

• Restriction: Restricted to graduate students

• Terms
  • Fall 2024
• Instructors
  • Corinne Hoesli