Biomanufacturing Core Courses

Below is a list of the core Biomanufacturing courses for students in the Master's non-thesis program. Please see Policies & Forms for more information about course requirements.

* Each course outline linked to on this page may be from a previous term and may not accurately represent current or future versions of the course.

BIEN 500 Special Topics in Bioeng 1 3 Credits

Offered in the:

Fall
Winter
Summer

Bioengineering: Selected special topics in bioengineering, given by current and visiting staff.

Offered by: Bioengineering

Prerequisite: Permission of instructor
Restriction: Open to U4 or higher students.
(3-0-6)

Terms
- This course is not scheduled for the 2024 academic year
Instructors
- There are no professors associated with this course for the 2024 academic year

Course description for 2022 Fall: Current Good Manufacturing Practices (cGMP) are vital for maintaining the quality standard of any biomanufacturing plant (for enzymes, hormones, DNA and 香蕉视频 gene therapy products, antibodies, medical and diagnostic devices) and during product commercialization. This course is delivered as a series of invited lectures from R&D and quality-control experts from biotechnology industries and research units in and around Canada. You will learn the key requirements and regulatory elements that form the foundation for commercializing biologics.

BIEN 580 Synthetic Biology 3 Credits

Offered in the:

Fall
Winter
Summer

Bioengineering: Engineering principles in biology, BioBricks and standardization of biological components, parts registries, advanced molecular biology tools for DNA assembly, genome editing, high-throughput genetic manipulation methods, construction of biological pathways, strategies for transcriptional control, examples of engineered systems.

Offered by: Bioengineering

Restriction: Permission of instructor
1. (3-2-4)

Terms
- Winter 2025
Instructors
- Codruta Ignea

BIEN 585 Metabolic Engineering 3 Credits

Offered in the:

Fall
Winter
Summer

Bioengineering: Metabolic engineering role in transition from fossil resources to a bio-based society. Design-build-test-learn cycle of metabolic engineering. Design, genetic engineering and optimization of microbial biocatalysts. Metabolic network analysis, constraint-based modelling of metabolism, microbial production of valuable chemicals. General biochemical engineering practices. Recombinant DNA technology, enzyme function, kinetics and regulation. Cell chemistry, structure and function. Growth models, fermentation, strain development. Case studies.

Offered by: Bioengineering

3-2-4
Prerequisite: Permission of the instructor.

Terms
- Fall 2024
Instructors
- Codruta Ignea

BIEN 590 Cell Culture Engineering 3 Credits

Offered in the:

Fall
Winter
Summer

Bioengineering: Basic principles of cell culture engineering, cell line development and cell culture products途 genomics, proteomics and post-translational modifications途 elements of cell physiology for medium design and bioprocessing途 bioreactor design, scale-up for animal cell culture and single use equipment途 challenges in downstream processing of cell-culture derived products途 process intensification: fed-batch, feeding strategies and continuous manufacturing途 scale-down and process modeling途 Process Analytical technologies and Quality by Design (QbD) concept.

Offered by: Bioengineering

(3-0-6)
Prerequisite: Permission of instructor.

Terms
- Fall 2024
- Winter 2025
Instructors
- Mario Jardon
- Mario Jardon, Amine A Kamen

BIEN 670 Downstream Processing 3 Credits

Offered in the:

Fall
Winter
Summer

Bioengineering: Introduction to downstream processing (DSP) 鈥� principles, characteristics, purpose. Bioprocesses, biomolecules, drug substances, drug products, monoclonal antibodies and Fc fusion proteins, viral vectors, and vaccines. Unit operations - standard practices. Steps and techniques in downstream processing. Harvest and Filtration, Primary capture, Buffer exchange and up-concentration, Purification, Bioconjugation, Formulation. Optimization of downstream processing. Process Analytical Technology (PAT) to support Quality by Design (QbD) in DSP. Regulatory guidelines. Innovative Techniques for Downstream Bioprocessing.

Offered by: Bioengineering

Prerequisites: BIEN 590 or permission of the instructor

Terms
- Fall 2024
Instructors
- Ayyappasamy Sudalaiyadum Perumal

BIEN 675 Proc Anlytcal Technos&DataScis 3 Credits

Offered in the:

Fall
Winter
Summer

Bioengineering: Introduction to Process Analytical Technologies (PAT) and Quality by Design (QbD) in the area of manufacturing biologics. Critical Process Parameters (CPP) and Design Space. Analytical Technologies for Biologics and Biologic Medicines and determination of Critical Quality Attributes of products. Case studies. At-line, On-line and Off-line monitoring tools, data acquisition and advanced process control strategies as applied to current industrial biomanufacturing. PAT data processing and modeling to design advanced biomanufacturing processes.

Offered by: Bioengineering

Prerequisites: BIEN 590 or permission of the instructor.

Terms
- Fall 2024
Instructors
- Shawn Chahal, Amine A Kamen

BIEN 680 Bioprocessing of Vaccines 4 Credits

Offered in the:

Fall
Winter
Summer

Bioengineering: Building on recent developments and expansion in the mammalian cell culture for production of complex biologics such as viral vaccines and viral vectors, the following topics will be covered: Principles of immunology and industrial virology; Cell physiology for vaccine production; Cell lines for vaccine production; Upstream process development and process intensification strategies; Purification and downstream processing of viral vaccines; Analytical and potency assays; Formulations and delivery of vaccines; Basics of clinical trials and regulatory principles; Immunization policies. Case studies on bioprocessing/manufacturing licensed vaccines.

Offered by: Bioengineering

Prerequisite: Permission of Instructor.

Terms
- Winter 2025
Instructors
- Mario Jardon

BIEN 685 Gene&Cell Ther Vrl Vecs Biomfc 3 Credits

Offered in the:

Fall
Winter
Summer

Bioengineering: Basic knowledge in the design and biomanufacturing of viral vectors for gene and cell therapy interventions. Practical examples and case studies highlighting challenges and solutions associated with use of viral vectors such as Adeno-Associated Vectors (AAV), lentivirus vectors and Adenovirus vectors for gene delivery. Fundamental principles of gene and cell therapies through in-vivo and ex-vivo interventions. Design of AAV, Lentivirus and Adenovirus vectors: example of targeted diseases, including CAR-T cell therapy. Technologies and modes of vector manufacturing for clinical use.

Offered by: Bioengineering

Prerequisites: BIEN 590 or permission of the instructor
Restrictions: Not open to students who have taken or are taking BIEN 680

Terms
- Winter 2025
Instructors
- Amine A Kamen

BMDE 505 Cell and Tissue Engineering 3 Credits

Offered in the:

Fall
Winter
Summer

Biomedical Engineering: Application of the principles of engineering, physical, and biological sciences to modify and create cells and tissues for therapeutic applications will be discussed, as well as the industrial perspective and related ethical issues.

Offered by: Biomedical Engineering

(3-0-6)
1.5 hours lecture/1.5 hours seminar per week
Restriction: graduate and final year undergraduate students from physical, biological, and medical science, and engineering.

Terms
- Winter 2025
Instructors
- Satya Prakash

BMDE 507 Formltn & Deliv of Biotherapeu 3 Credits

Offered in the:

Fall
Winter
Summer

Biomedical Engineering: Introduction to technologies for formulation and delivery of biotherapeutics. Emphasis is placed on the fundamental principles of formulation, delivery systems, manufacturing, analytical techniques, and biomedical applications. Translational aspects are considered for formulated biotherapeutic products.

Offered by: Biomedical Engineering

Prerequisites CHEE 380 (or equivalent), CHEM 212 (or equivalent), and BIOL 201 (or equivalent), or permission of the instructor.

Terms
- Fall 2024
Instructors
- Guojun Chen

CHEE 512 Stem Cell Bioprocess Eng. 3 Credits

Offered in the:

Fall
Winter
Summer

Chemical Engineering: Introduction to stem cell biology. Cell growth models applicable to stem cells and their progeny. Upstream processing (cell culture systems, bioreactors), downstream processing (cell separation, purification) and quality management (current good manufacturing practice, regulations) applied to therapeutic cells.

Offered by: Chemical Engineering

(3-0-6)
Prerequisite(s): MATH 262 and CHEE 370 or BIOL 200, or Permission of Instructor.
Restriction: Open to undergraduate and graduate students registered in Chemical Engineering, as well as graduate students registered in the McGill Graduate Certificate in Regenerative Medicine program or in the M.Eng. in Biological and Biomedical Engineering program.

Terms
- This course is not scheduled for the 2024 academic year
Instructors
- There are no professors associated with this course for the 2024 academic year

CHEE 651 Adv Biochemical Engineering 4 Credits

Offered in the:

Fall
Winter
Summer

Chemical Engineering: The use of chemical engineering and biological principles in the study, design, use and creation of biologically-based processes and products. Topics: biochemical thermodynamics, protein engineering, manipulation of gene expression, transport phenomena and bioreactor design.

Offered by: Chemical Engineering

Restriction: Restricted to graduate students

Terms
- Fall 2024
Instructors
- Corinne Hoesli

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Biomanufacturing Core Courses

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Graduate Program in Biological and Biomedical Engineering