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The research of Jorge Angeles聽centers on the design and control of large-scale robotic mechanical systems and their individual components, including drives and sensors. A significant aspect of Angele's work involves the development of speed reducers that meet the stringent requirements of robotic and mechatronic applications, focusing on low backlash, minimal friction, and high stiffness. To surpass conventional gears, they are actively exploring the potential of cam-roller transmissions.

In terms of robot design, Angeles places a strong emphasis on ensuring robustness concerning kinetostatic, elastostatic, and elastodynamic performance. His research in the domain of robotic mechanical systems is particularly focused on lower-mobility parallel robots, with a special focus on Schoenflies-motion generators, also known as parallel SCARA systems. Additionally, ongoing research efforts in the field of design theory and methodology are part of their academic pursuits.