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Dr. Nicolau's research interests include: design and fabricate dynamic hybrid nanodevices comprising linear protein molecular motors working on semiconductor manufactured electro-mechanical devices; design and fabricate ‘smart’ micro/nano-profiled and electrically-active surfaces that combinatorially probe the response of biomolecules for micro/nano-array applications; study effective, non-denaturating technologies for immobilization of biomolecules in static and dynamic biodevices; and study intelligent-like behaviour and algorithms used by microorganisms in their survival and search strategies, probed in microfabricated structures.