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Program Requirements
Thesis
A thesis for the doctoral degree must constitute original scholarship and must be a distinct contribution to knowledge. It must show familiarity with previous work in the field and must demonstrate ability to plan and carry out research, organize results, and defend the approach and conclusions in a scholarly manner. The research presented must meet current standards of the discipline; as well, the thesis must clearly demonstrate how the research advances knowledge in the field. Finally, the thesis must be written in compliance with norms for academic and scholarly expression and for publication in the public domain.
Required Courses (7 credits)
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BIOC 610 Seminars in Chemical Biology 1 (1 credit)
Overview
Biochemistry : First multidisciplinary seminar in chemical biology.
Terms: Fall 2012, Winter 2013
Instructors: Silvius, John R (Fall)
Restrictions: Open only to students registered for the M.Sc. or Ph.D. Graduate Option in Chemical Biology.
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BIOC 611 Seminars in Chemical Biology 3 (1 credit)
Overview
Biochemistry : Third multidisciplinary seminar in chemical biology.
Terms: Fall 2012, Winter 2013
Instructors: Silvius, John R (Fall)
Restrictions: Open only to students registered for the M.Sc. or Ph.D. Graduate Option in Chemical Biology.
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BIOC 689 Seminars in Chemical Biology 2 (1 credit)
Overview
Biochemistry : Second multidisciplinary seminar in chemical biology.
Terms: Fall 2012, Winter 2013
Instructors: Silvius, John R (Fall) Silvius, John R (Winter)
Restrictions: Open only to students registered for the M.Sc. or Ph.D. Graduate Option in Chemical Biology. Not open to students who have taken CHEM 689.
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BIOC 690 Seminars in Chemical Biology 4 (1 credit)
Overview
Biochemistry : Fourth multidisciplinary seminar in chemical biology.
Terms: Fall 2012, Winter 2013
Instructors: Silvius, John R (Fall) Silvius, John R (Winter)
Restrictions: Open only to students registered for the M.Sc. or Ph.D. Graduate Option in Chemical Biology. Not open to students who have taken CHEM 690.
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BIOC 696 Seminars in Biochemistry (3 credits) *
Overview
Biochemistry : Seminars in biochemistry.
Terms: Fall 2012, Winter 2013
Instructors: There are no professors associated with this course for the 2012-2013 academic year.
Restriction: Open to M.Sc. and Ph.D. Biochemistry students only.
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BIOC 701 Research Seminar 1 **
Overview
Biochemistry : Presentation on original current laboratory research carried out by student.
Terms: Fall 2012, Winter 2013
Instructors: There are no professors associated with this course for the 2012-2013 academic year.
Biochemistry graduate students
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BIOC 702 Ph.D. Thesis Proposal **
Overview
Biochemistry : Dissertation presented to Committee.
Terms: Fall 2012, Winter 2013
Instructors: There are no professors associated with this course for the 2012-2013 academic year.
Biochemistry graduate students
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BIOC 703 Research Seminar 2 **
Overview
Biochemistry : Presentation of the planned thesis including central findings and original contribution to knowledge in the field of research.
Terms: Fall 2012, Winter 2013
Instructors: There are no professors associated with this course for the 2012-2013 academic year.
Restriction: Ph.D. students in Biochemistry
* Students promoted directly from the M.Sc. to the Ph.D. program, and who registered for and passed BIOC 696 at the M.Sc. level, do not register for BIOC 696 at the Ph.D. level.
** NOTE: Students DO NOT register for these courses until notified by the Student Affairs Officer.
Students must complete BIOC 701 in the third term after admission to the program, BIOC 702 in the fifth or sixth term, and BIOC 703 approximately six months prior to submission of the Ph.D. thesis.
Complementary Courses*** (9 credits)
At least 3 credits from the following:
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CHEM 502 Advanced Bio-Organic Chemistry (3 credits)
Overview
Chemistry : This course will cover biologically relevant molecules, particularly nucleic acids, proteins, and their building blocks. In each case, synthesis and biological functions will be discussed. The topics include synthesis of oligonucleotides and peptides; chemistry of phosphates; enzyme structure and function; coenzymes, and enzyme catalysis; polyketides; antiviral and anticancer agents.
Terms: Winter 2013
Instructors: Auclair, Karine; Pavelka, Laura (Winter)
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CHEM 503 Drug Design and Development 1 (3 credits)
Overview
Chemistry : Interdisciplinary course in drug design and development covering combinatorial chemistry, process chemistry, structure-activity relationship, pharmacokinetics and metabolism, mechanisms of action and steps in drug development, and principles and problems in drug design.
Terms: Fall 2012
Instructors: Moitessier, Nicolas (Fall)
- PHAR 503 Drug Discovery and Development 1 (3 credits)
At least 3 credits from the following:
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BIOC 570 Biochemistry of Lipoproteins (3 credits)
Overview
Biochemistry : Structure, function and metabolism of lipids and lipoproteins as they relate to lipid storage diseases, obesity, diabetes and heart disease.
Terms: This course is not scheduled for the 2012-2013 academic year.
Instructors: There are no professors associated with this course for the 2012-2013 academic year.
Winter
Prerequisite: BIOC 311 or equivalent
Restriction: Open to U3 and graduate students
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BIOC 600 Advanced Strategies in Genetics and Genomics (3 credits)
Overview
Biochemistry : Advanced technologies and methods in genomics research, presented by experts actively pursuing the experimental approaches discussed.
Terms: This course is not scheduled for the 2012-2013 academic year.
Instructors: There are no professors associated with this course for the 2012-2013 academic year.
Enrolment limited to 15 graduate students.
Prerequisite: BIOC 454 or equivalent
Restriction: Must take part in the Biochemistry graduate program
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BIOC 603 Genomics and Gene Expression (3 credits)
Overview
Biochemistry : Examination of recent developments in analysis of eukaryotic cell genomes and control of gene expression. Molecular genetics; genomics and the bioinformatics of analysis of genomic and functional-genomic data; mechanisms and signal-transduction pathways for regulation of gene expression; applications to human disease.
Terms: Fall 2012
Instructors: Muller, William Joseph; Teodoro, Jose Guerreiro; Gallouzi, Imed Eddine (Fall)
Fall
Prerequisites: BIOC 454 and permission of instructor.
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BIOC 604 Macromolecular Structure (3 credits)
Overview
Biochemistry : X-Ray crystallography, NMR spectroscopy, computational methods and theoretical approaches to the determination and analysis of macromolecular structures. Theory and practical applications will be covered. Examples will include interpretation of structure as it applies to biological functions. In conjunction with the Université de Montréal.
Terms: Winter 2013
Instructors: Nagar, Bhushan (Winter)
Winter
Prerequisite: BIOC 450 or equivalent
Lectures in French and English
Offered in the Fall term, in even alternate years.
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BIOC 605 Structural Biology and Proteomics (3 credits)
Overview
Biochemistry : Examination of recent developments in structural biology and proteomics analysis. Diffraction, NMR and modelling approaches to macromolecular structure; biophysical, proteomics and related approaches to characterize the physical and functional interactions of biological macromolecules; applications to biological problems.
Terms: Winter 2013
Instructors: Young, Jason (Winter)
Winter
Prerequisite: BIOC 450 or equivalent, or permission of instructor.
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EXMD 615 Essentials of Glycobiology (3 credits)
Overview
Experimental Medicine : Examination of the structure, function, and biosynthesis of glycoproteins, glycolipids and glycosaminoglycans, and the biological role of complex carbohydrates. Lectins, methods for elucidating carbohydrate structure, glycomics, and human diseases due to disorders of glycan synthesis.
Terms: Winter 2013
Instructors: Gilfix, Brian (Winter)
Winter
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EXMD 635D1 Experimental/Clinical Oncology (3 credits)
Overview
Experimental Medicine : The course will deal, on a site by site basis, with the incidence of cancer, present treatment, treatment outcome, underlying causes, current research and directions for development of new treatments. Chemotherapy, surgery, radiation therapy and nutrition as therapy and treatment of cancer will be included.
Terms: Fall 2012
Instructors: Hadjopoulos, Maria (Fall)
Students must register for both EXMD 635D1 and EXMD 635D2
No credit will be given for this course unless both EXMD 635D1 and EXMD 635D2 are successfully completed in consecutive terms
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EXMD 635D2 Experimental/Clinical Oncology (3 credits)
Overview
Experimental Medicine : See EXMD 635D1 for course description.
Terms: Winter 2013
Instructors: Hadjopoulos, Maria (Winter)
Prerequisite: EXMD 635D1
No credit will be given for this course unless both EXMD 635D1 and EXMD 635D2 are successfully completed in consecutive terms
Plus additional credits to a total of at least 9 complementary course credits from the following list:
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CHEM 504 Drug Design and Development 2 (3 credits)
Overview
Chemistry : Computational methods used in drug design and discovery including QSAR, docking/scoring, molecular mechanics and molecular dynamics, QM/MM, library profiling and library design.
Terms: This course is not scheduled for the 2012-2013 academic year.
Instructors: There are no professors associated with this course for the 2012-2013 academic year.
Winter
Prerequisite: CHEM 503 and permission of instructor
Restriction: U3 and graduate students. Students can register only with permission of coordinators
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CHEM 522 Stereochemistry (3 credits)
Overview
Chemistry : Stereoisomers, their nomenclature and configuration. Conformational analysis, separation of stereoisomers, and stereocontrol in organic synthesis.
Terms: Fall 2012
Instructors: Moitessier, Nicolas (Fall)
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CHEM 582 Supramolecular Chemistry (3 credits)
Overview
Chemistry : Introduction to supramolecular organization will be followed by discussions on the nature of interactions and methodologies to create ordered aggregates of high complexity. Potential of supramolecular chemistry in fabricating smart materials will be explored using specific topics including inclusion chemistry, dendrimers, molecular self-assembly and crystal engineering.
Terms: Winter 2013
Instructors: Sleiman, Hanadi (Winter)
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CHEM 591 Bioinorganic Chemistry (3 credits)
Overview
Chemistry : The roles of transition and main group elements in biology and medicine will be examined with an emphasis on using tools for structure and genome searching as well as becoming acquainted with experimental spectroscopic methods useful for bioinorganic chemistry such as macromolecular X-ray diffraction, EPR and EXAFS.
Terms: Winter 2013
Instructors: Bohle, David (Winter)
Winter
Prerequisite: CHEM 381
Restriction: For Honours and Major Chemistry students or with permission
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CHEM 621 Reaction Mechanisms in Organic Chemistry (5 credits)
Overview
Chemistry : A systematic survey of the mechanisms of the most common organic reactions from studies of reactions in the current literature.
Terms: Fall 2012
Instructors: Li, Chaojun (Fall)
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CHEM 629 Organic Synthesis (5 credits)
Overview
Chemistry : An advanced course in the synthesis of organic molecules with an emphasis on stereoselective transformations. Topics will include multiple bond formation, functional group interconversions, carbon-carbon bond formation and stereoselective oxidations and reductions.
Terms: Winter 2013
Instructors: Lumb, Jean-Philip (Winter)
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CHEM 655 Advanced NMR Spectroscopy (4 credits)
Overview
Chemistry : Advanced techniques of nuclear magnetic resonance spectroscopy, Fourier transform methods, multiple pulsing, two-dimensional pulse sequencing.
Terms: Winter 2013
Instructors: Mittermaier, Anthony (Winter)
1 lecture
Prerequisite: CHEM 555 or equivalent.
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EXMD 510 Bioanalytical Separation Methods (3 credits)
Overview
Experimental Medicine : The student will be taught the capabilities and limitations of modern separation methods (gas and high-performance liquid chromatography, capillary electrophoresis, hyphenated techniques). Application of these techniques to solve analytical problems relevant to biomedical research will be emphasized, with special attention being paid to the processing of biological samples.
Terms: Fall 2012
Instructors: Jean-Claude, Bertrand (Fall)
Fall
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EXMD 602 Techniques in Molecular Genetics (3 credits)
Overview
Experimental Medicine : Precise description of available methods in molecular genetics, and rationales for choosing particular techniques to answer questions posed in research proposals for targeting genes in the mammalian genome. Emphasis placed on analysis of regulation of gene expression and mapping, strategies for gene cloning. Course divided between lectures and student seminars.
Terms: Winter 2013
Instructors: Malo, Danielle; Radzioch, Danuta (Winter)
Offered in conjunction with the Department of Experimental Medicine.
Prerequisite (Graduate): Admission by permission of instructor.
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PHAR 504 Drug Discovery and Development 2 (3 credits)
Overview
Pharmacology and Therapeutics : Nobel Prize-winning discoveries as a basis for drug development.
Terms: Winter 2013
Instructors: Maysinger, Dusica (Winter)
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PHAR 562 General Pharmacology 1 (3 credits)
Overview
Pharmacology and Therapeutics : Topics in pharmacology with an emphasis on molecular aspects and the nervous system; topics include molecular mechanisms of drug-action, cellular targets and rationale for therapeutics.
Terms: Fall 2012
Instructors: Almazan, Guillermina (Fall)
Fall
Prerequisite: PHAR 301.
Restriction: Open to U3 students in the minor, major or honours program in Pharmacology, or with permission of instructor.
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PHAR 563 General Pharmacology 2 (3 credits)
Overview
Pharmacology and Therapeutics : Selected topics in pharmacology of the endocrine, metabolic, and cardiovascular systems. Additional topics include: pharmacogenetics/pharmacogenomics, chronopharmacology, molecular structure in pharmacology, epigenetic targets in cancer chemotherapy, and stem cell therapies.
Terms: Winter 2013
Instructors: Tanny, Jason (Winter)
Winter
Prerequisite: PHAR 301.
Restriction: Open to U3 students in the minor, major or honours program in Pharmacology, or with permission of instructor.
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PHAR 707 Topics in Pharmacology 6 (3 credits)
Overview
Pharmacology and Therapeutics : Topics in pharmacology.
Terms: Fall 2012
Instructors: Culty, Martine (Fall)
Prerequisite: Permission of the Instructor.
*** Complementary courses are chosen in consultation with the Research Director.
The Graduate Advisory Committee may stipulate additional coursework depending on the background of the candidate. BIOC 450 (Protein Structure and Function) and BIOC 454 (Nucleic Acids) are additional requirements for those who have not previously completed equivalent courses in their prior training.
Faculty of Medicine—2012-2013 (last updated Dec. 20, 2012) (disclaimer)