Ï㽶ÊÓƵ

The Feindel Brain and Mind Seminar Series will advance the vision of Dr. William Feindel (1918–2014), Former Director of the Neuro (1972–1984), to constantly bridge the clinical and research realms. The talks will highlight the latest advances and discoveries in neuropsychology, cognitive neuroscience, and neuroimaging.

Speakers will include scientists from across The Neuro, as well as colleagues and collaborators locally and from around the world. The series is intended to provide a virtual forum for scientists and trainees to continue to foster interdisciplinary exchanges on the mechanisms, diagnosis and treatment of brain and cognitive disorders.

To watch online, click 

Role of Dopamine in Decision Making and Cognitive Control

Abstract: Dopamine has long been implicated in the cognitive control of behavior. Cognitive deficits are common in disorders that implicate dopamine, such as Parkinson’s disease, addiction, ADHD, and depression, and such deficits are often treated with dopaminergic drugs. Roshan will review recent studies in which her team have combined pharmacological interventions with neuroimaging and computational modeling to unravel dopamine’s role in behavioral control. Results suggest key contributions of striatal dopamine-dependent changes in lower-order learning and decision parameters to changes in higher-order cognitive control. The work also illustrates how computational model-derived inference of striatal dopaminergic learning parameters can help predict changes in clinically relevant behavioral control problems including impulse control disorder in Parkinson’s disease.

Roshan Cools

Professor of Cognitive Neuropsychiatry, Donders Institute for Brain, Cognition and Behaviour & Department of Psychiatry, Radboud University Medical Center

Roshan Cools is Principal Investigator at the Donders Institute for Brain, Cognition and Behaviour and Professor of Cognitive Neuropsychiatry at the Radboud University Medical Center. She is an expert in the chemical neuromodulation of human cognition and motivation. Her PhD is from the University of Cambridge (UK), where she held Royal Society research fellowships and did a postdoc at the Helen Wills Neuroscience Institute at UC Berkeley. At the Donders, she steers an active research group (), combining psychopharmacology, fMRI, chemical PET imaging, computational cognitive modelling, neurostimulation and patient work to unravel how behavioral control strategies are adaptively tuned to our constantly changing environment, modulated by the major ascending neuromodulators, including dopamine, serotonin and noradrenaline. She holds a Horizon Europe ERC Advanced grant, is a lead scientist of the Human Brain Project, and is a member of the Royal Netherlands Academy of Arts and Sciences (KNAW).