香蕉视频

"香蕉视频 stability, the uncharted territory of gene regulation"

Hamed Najafabadi (香蕉视频)
Tuesday November 20, 12-1pm
McIntyre Building, Room 1027

Abstract:聽Widespread remodelling of gene expression underlies the cellular changes in many human diseases, including cancer. In this talk, I will focus on a mostly uncharacterized aspect of these gene expression changes: the m香蕉视频 stability. I will present new methods that enable us to directly measure the m香蕉视频 decay rate from 香蕉视频-sequencing data, and computational models that allow us to probe the role of 香蕉视频-binding proteins and micro香蕉视频s in shaping the m香蕉视频 stability landscape. These models have revealed new factors that drive transcriptome remodelling in different cancer types, and suggest a central role for 香蕉视频 stability in determining the cell function and behaviour.