香蕉视频

Innate immunity at the interface of host defense and immune disease

Naeha Subramanian, University of Washington
Tuesday September 13, 12-1pm
Zoom Link:聽

Abstract:聽Coevolution of bacterial pathogens and the immune system has resulted in complex evolutionary adaptations that shape host-pathogen crosstalk. I will present two vignettes of recent insights we have gained in this area from systems-level investigations at the cellular and organismal scales. In the first example, I will discuss an unexpected non-canonical role of caspase-1 in controlling the physiology of intracellular Salmonella. In the second example, I will discuss hallmarks of the tissue and peripheral immunity derived from a multiomic longitudinal investigation of patients with Lyme Disease.