香蕉视频

We are all familiar with the drawbacks of dehydration, but we rarely hear about the harmful effects of overhydration. It is known that excess fluid accumulation can lead to dangerously low sodium levels in the blood or hyponatremia 鈥� a life-threatening condition that can result in brain swelling. Similarly, more is known about the mechanisms in the body that detect and drive thirst while little is known about how the brain detects a state of overhydration.

鈥淸Hyponatremia] occurs in common pathological conditions, including brain injury, sepsis, cardiac failure and in the use of drugs, such as MDMA (ecstasy),鈥� says Dr. Charles Bourque, whose team from the Centre for Research in Neuroscience at the Research Institute of the 香蕉视频 Health Centre (RI-MUHC) uncovered a key piece to the puzzle of how our brains detect hyponatremia and regulate overhydration. The new study featured in Cell Reports unearths the fundamental mechanism of how hyponatremia is detected in the brain.

鈥淥ur specific data will be important for people studying hydromineral and fluid electrolyte homeostasis, and clinicians who treat patients faced with hyponatremia,鈥� reports Dr. Bourque, who is a scientist in the Brain Repair and Integrative Neuroscience Program (BRAIN) at the RI-MUHC and a professor in McGill鈥檚 Department of Neurology. This condition is more common in elderly patients and can cause cognitive problems and seizures in this vulnerable group. While it remains uncertain how hyponatremia develops, a defect in the hydration sensing mechanism of the brain could be the culprit.

No strangers to studying the mechanisms of hydration in the body, Dr. Bourque鈥檚 team, located at the Montreal General Hospital, has also made several key discoveries in the past on how the brain detects and prevents dehydration; how salt intake increases blood pressure; and how the brain鈥檚 biological clock stimulates thirst prior to sleep. In this instance, experiments by first study鈥檚 author Sorana Ciura, a PhD student in Dr. Bourque鈥檚 laboratory, who is now at the Institut Imagine, H么pital Necker-Enfants Malades in Paris, revealed that the brain鈥檚 hydration sensing neurons don鈥檛 detect overhydration in the same way that they detect dehydration.

Inhibiting hydration sensing neurons

The new research shows that overhydration activates Trpv4, which is a cellular gatekeeper implicated in maintaining the balance of water in the body. Trpv4 is a calcium channel that can be found in glial cells, which are cells that act to surround hydration sensing neurons.

鈥淥ur study shows that it is in fact glial cells that first detect the overhydrated state and then transfer this information to turn off the electrical activity of the [hydration sensing] neurons,鈥� explains Dr. Bourque. The researchers also found that it is the release of the amino acid taurine that acts to inhibit hydration sensing neurons. Essentially, when overhydration is detected by glial cells, the Trpv4 channel triggers the release of taurine, which acts as a trip wire to inhibit hydration sensing neurons.听听

Hope for patients with hyponatremia

The brain鈥檚 ability to detect excess hydration is essential to maintaining fluid balance in the body and preventing conditions like hyponatremia. 鈥淧reclinical models of hyponatremia will be used to examine if the mechanism we report is affected in this condition with the long-term objective of designing new treatments or diagnostic tools,鈥� says Dr. Bourque.

鈥淗yponatremia is common with as many as one-quarter of hospitalized patients suffering from a traumatic brain injury developing the condition,鈥� says Dr. Judith Marcoux, a neurosurgeon at the Montreal General Hospital of the MUHC, who collaborates with Professor Bourque to define the basis for the emergence of hyponatremia in patients that suffer from a traumatic brain injury (TBI).

鈥淣othing is really known about the mechanisms that lead to hyponatremia in these patients,鈥� Dr. Marcoux adds. 鈥樷�橦yponatremia can have catastrophic consequences such as causing seizures or leading to a coma, and raised intracranial pressure can cause further damage to the brain, which can lead to a decrease in neurological and functional outcomes for patients. 鈥�

This work was supported by grants from the Canadian Institutes of Health Research (CIHR) and the Heart and Stroke Foundation of Canada.

The study was co-authored by Sorana Ciura (Institut Imagine, H么pital Necker-Enfants Malades); Masha Prager-Khoutorsky, Zahra S. Thirouin, Joshua C. Wyrosdic and Charles W. Bourque (Centre for Research in Neuroscience, Research Institute of the 香蕉视频 Health Centre); James E.Olson (Wright state University); Wolfgang Liedtke (Centre for Translational Neuroscience, Duke University Medical Centre).
DOI: 10.1016/j.celrep.2018.04.090

About the Research Institute of the MUHC

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The Research Institute of the 香蕉视频 Health Centre (RI-MUHC) is a world-renowned biomedical and healthcare research centre. The Institute, which is affiliated with the Faculty of Medicine of 香蕉视频, is the research arm of the 香蕉视频 Health Centre (MUHC) 鈥� an academic health centre located in Montreal, Canada, that has a mandate to focus on complex care within its community. The RI-MUHC supports over 420 researchers and close to 1,200 research trainees devoted to a broad spectrum of fundamental, clinical and health outcomes research at the Glen and the Montreal General Hospital sites of the MUHC. Its research facilities offer a dynamic multidisciplinary environment that fosters collaboration and leverages discovery aimed at improving the health of individual patients across their lifespan. The RI-MUHC is supported in part by the Fonds de recherche du Qu茅bec 鈥� Sant茅 (FRQS).

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