Thomas Murray, PhD (University of Minnesota)
Epidemiology, Biostatistics and Occupational Health Seminar.
°Õ¾±³Ù±ô±ð:ÌýRecent Experiences Conducting Trials using Bayesian Response Adaptive Randomization
´¡²ú²õ³Ù°ù²¹³¦³Ù:ÌýThomas Murray is an Assistant Professor and Medtronic Faculty Fellow in the Division of Biostatistics at the University of Minnesota School of Public Health. His methodological research interests include decision-making in clinical trials with multiple outcomes, incorporating external data into clinical trial analyses and data monitoring, and adaptive design in general. His collaborative research has largely been in cardiology, oncology and behavioral science. During the past two years, he has devoted much effort to help design and manage data coordination for clinical trials evaluating therapeutics for Covid-19. That, and raising two wonderful but exhausting young children with his spouse.
I will discuss my experiences coordinating two recent clinical trials in out-of-hospital cardiac arrest that used Bayesian response adaptive randomization designs, and present some methodological innovations to improve implementation and understand the potential benefit these designs offer. I will discuss the ACCESS trial (Clinicaltrials.gov ID: NCT03119571), which sought to compare the efficacy of two standards or care: direct admission to the cardiac catheter laboratory versus the ICU; and the ARREST trial (NCT03880565), which sought to evaluate the efficacy of in-transit ECMO-facilitated resuscitation versus standard Advanced Cardiac Life Support (ACLS) resuscitation. My experiences with these trials motivated methodological research into alternative prior choices and randomization techniques that improve type I error control and reduce the risk of enrolling a substantial proportion of participants to an inferior treatment arm. Building upon this research, we proposed and investigated comparing a set of potential designs in terms of the expected number of failures among the cohort most acutely affected by the choice of design; namely, persons who would participate in the trial if it were open to enrollment at the time they become eligible. I plan to discuss the details and take-aways from this line of research.
Zoom - Please contact: admincoord.eboh [at] mcgill.ca
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