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PhD Oral Defense of听Vahid H Gazestani,听Institute of Parasitology

Trypanosomatid pathogens, causative agents of serious diseases in humans and animals, are听vector-borne parasites with intricate life cycle. These pathogens rely on fine regulation of 听gene听expression to respond and adapt to variable environments, with implications in transmission and听infectivity. Unlike mammals (hosts) or most other eukaryotes, trypanosomatid gene regulation听occurs at the post-transcriptional level mostly through interaction of trans-acting 香蕉视频-binding听proteins (RBPs) and cognate cis-acting sequence elements (卢香蕉视频 Regulatory Elements, RREs)听that direct m香蕉视频 maturation, localization, stability, and translation rate. However, these听regulatory elements and their mechanisms of actions are largely unknown. In this thesis, we use听integrated computational experimental strategies to unravel the regulatory circuits听controlling 香蕉视频 processing and abundance in these human parasites that can be eventually听exploited to identify novel chemotherapeutics.

Everyone in the McGill community is welcome to attend a PhD oral defense. Please join us in celebrating the accomplishments of our PhD candidates.

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