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PhD Oral Defence of Jordan Demone, Plant Science

The SAGA complex is an important chromatin modification complex and activates nearly 10% of the Saccharomyces cerevisiae genome. SAGA (SPT-ADA2-GCN5-acetyltransferase) is a 1.8 mDa conglomeration of proteins composed of four separate but cooperative modules: the DUB (deubiquitination) module, the TAF module, the SPT module, and the HAT (histone acetyltransferase) module, all of which promote gene expression. This work focused on characterizing ADA2 in the model monocot Brachypodium distachyon.

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