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Bernice Grafstein Lecture in Neuroscience

Thursday, October 28

3-5 PM

Registration is mandatory in order to attend the event. The Zoom meeting link and details will be e-mailed to registrants 1-2 days before the event date.

Key Note Speaker: Dr. Lawrence Wald

Topic:"Addressing barriers in high field fMRI acquisitions"

MRI acquisition methodology has concentrated on the considerable engineering challenges of rapidly applying the strong magnetic fields needed to polarize the spins, rapidly encode the spatial information and sensitively detect the MR signal. Happily, many pure engineering challenges have fallen. For example, the latest gradient coils under development handle unprecedented heat removal, current, voltage, force, torque, eddy current and other gradient-magnet interactions. These successes have forced us to confront biological ceilings imposed by the stimulation of peripheral nerves during gradient switching. Also, the MR gradient coil is now no-longer alone in its role of encoding the image information. The detector array has improved to the point where it produces the majority of the final Nyquist-sampled data space, as opposed to being encoded in the signal by the gradient coil.

In this talk, I describe our attempts to improve these two sources of image encoding (gradient and detector coil array), and then pivot our methodology toward this view of shared image encoding to try to make them work better together. By dove-tailing the strengths and weaknesses of the gradient coil and detector array, we can go one step further and create new sampling strategies. Successful recent offspring of this marriage include “blipped-CAIPI” Simultaneous MultiSlice (SMS) fMRI, “wave-CAIPI” anatomical imaging and EPTI for either fMRI or anatomical imaging, and finally, a new capability to extend the image reconstruction to non-stationary objects and thus mitigate motion confounds.

 
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