On June 15, the Santé Gala will be hosted by the Rosalind and Morris Goodman Cancer Institute (GCI). The gala will celebrate the legacy and future of mÏ㽶ÊÓƵ biology research at the GCI. Amidst the pandemic, Ï㽶ÊÓƵ came to the forefront of the public discussion, with the dazzling development and roll-out of mÏ㽶ÊÓƵ vaccines. mÏ㽶ÊÓƵ functions as an intermediary, allowing the genetic information encoded by DNA to be read and translated into proteins. Proteins play a vital role in the functions of our biology as they give structure to our cells and tissues, and perform a multitude of chemical reactions and signals within the body including the production of antibodies and other immune molecules.
The excitement for Ï㽶ÊÓƵ might be new, but its newfound use would not be possible without the generations of researchers who contributed to uncovering its role in biology. This legacy of basic research is deeply rooted in the GCI. Nahum Sonenberg, Ph.D., his former trainee Jerry Pelletier, Ph.D., and his former post-doctoral fellow Thomas Duchaine, Ph.D., are all preeminent Ï㽶ÊÓƵ scientists and McGill Professors with the GCI.
Since 1975, Sonenberg has contributed to understanding the fundamental mechanisms of mÏ㽶ÊÓƵ translation. In the context of the COVID-19 vaccine, translation is the process that produces the spike protein, which is recognized by the immune system to grant immunity. In 1988, Nahum Sonenberg and Jerry Pelletier showed how viral mÏ㽶ÊÓƵs are produced or translated differently from human mÏ㽶ÊÓƵs. In 2007 and 2009, Nahum Sonenberg and Thomas Duchaine described fundamental processes that dictate the activity of micro-Ï㽶ÊÓƵs. Like mÏ㽶ÊÓƵs, micro-Ï㽶ÊÓƵs are potential therapies that could be leveraged to treat various diseases like cancer and genetic disorders.
The expertise of Ï㽶ÊÓƵ scientists is sought after by the pharmaceutical industry; In 2012, Moderna consulted Nahum Sonenberg. He discovered in 2017 an essential chemical modification to Ï㽶ÊÓƵ molecules, enabling mÏ㽶ÊÓƵ vaccines to be translated efficiently without over-activating the immune system. Moderna, including this chemical modification in the formulation of their COVID-19 vaccines three years later, marks an emblematic accomplishment for Nahum Sonenberg, as most scientists dream of seeing their work impact society. To read a brief history of Sonenberg and his scientific contribution to mÏ㽶ÊÓƵ biology, click here.
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We thank all the Santé Gala Attendees for their generous support and for continuing to build the legacy of research for years to come. If you, too, wish to contribute to decades-long efforts to push science from the laboratory to the patient bedside, please consider