Dr. Terence Coderre
Associate Professor - Department of Anesthesia
Associate Member - Department of Medicine
Dr. Coderre’s main research interest is the pharmacological, neurochemical and anatomical characterization of mechanisms underlying neuroplasticity in the spinal cord dorsal horn and brain, and its influence on pain perception. Techniques used in our labs, and through interactions with our collaborators, include behavioural nociceptive testing, neuropharmacology, in vivo microdialysis, light and electron microscopic immunocytochemistry, autoradiography and image analysis. The purpose of these investigations is to provide integrated anatomical, neurochemical and physiological information on how excitatory amino acids, neuropeptides and growth factors interact with their receptors and intracellular messengers to induce states of noxious stimulus-induced plasticity in the central nervous system that lead to behavioural hyperalgesia or enhanced pain perception. The above information is important for our understanding of the mechanisms underlying persistent or chronic pain and, potentially, for the treatment of pain. A current focus is on changes in the internalization and trafficking of metabotropic glutamate receptors following persistent nociception, and their influence on the regulation of the release of excitatory amino acids in spinal cord dorsal horn, as well as hyperalgesia. He is also involved in studies on aimed at identifying specific mechanisms underlying the pathophysiology of complex regional pain syndrome (CRPS) using anatomical, behavioural, and neurochemical studies in animal models and near infrared spectroscopy in CRPS patients.
Ragavendran JV, Laferriere A, Xiao WH, Bennett GJ, Padi, SSV, Zhang J, Coderre TJ. Topical combinations for chronic pain aimed at treating microvascular dysfunction reduce allodynia in animal models of CRPS-I and neuropathic pain. J Pain . 2013 14: 66-78
Kumar N, Cherkas PS, Varathan V, Miyamoto M, Chiang CY, Dostrovsky JO, Sessle BJ, Coderre TJ. Systemic pregabalin attenuates facial hypersensitivity and noxious stimulus-evoked release of glutamate in medullary dorsal horn in a rodent model of trigeminal neuropathic pain. Neurochem Int . 2013 62:831-835
Vrolijk-de Mos M, Millecamps M, Laferièrre A, Pilkington M; Sturkenboom MCJM, Huygen FJPM, Coderre TJ. Role of NFκB in an animal model of complex regional pain syndrome - type I (CRPS-I). Journal of Pain. 2009 1161-1169
Xanthos DN, Kumar N, Theodorsson E, Coderre TJ. The roles of nerve growth factor and cholecystokinin in the enhancement of morphine analgesia in a rodent model of central nervous system inflammation. Neuropharmacology. 2009 Mar;56(3):684-91. Epub 2008 Dec 11.
Laferrière A, Millecamps M, Xanthos DN, Xiao WH, Siau C, Vrolijk-de Mos M, Sachot C, Ragavendran JV, Huygen FJPM, Bennett GJ, Coderre TJ. Cutaneous tactile allodynia associated with microvascular dysfunction in muscle. Mol Pain. 2008 4:49
Coderre TJ, Kumar N, Lefebvre CD, Yu JS. A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain. J Neurochem. 2007 Mar;100(5):1289-99. Epub 2007 Jan 11.
Pitcher MH, Ribeiro-da-Silva A, Coderre TJ. Effects of inflammation on the ultrastructural localization of spinal cord dorsal horn group I metabotropic glutamate receptors. J Comp Neurol. 2007 Dec 1;505(4):412-23.
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