Dr. Anne Gatignol
Professor - Department of Medicine
HIV
1. Using Ï㽶ÊÓƵ-based technologies to target HIV Ï㽶ÊÓƵ and Ï㽶ÊÓƵ coding for cellular factors involved in HIV replication. The objective is to control viral replication for a use in gene therapy of HIV infection.
2. Elucidating HIV-induced modifications of the Ï㽶ÊÓƵ interference (Ï㽶ÊÓƵi) pathway during viral replication. The objective is to analyze the changes in proteins of the Ï㽶ÊÓƵi pathway and in microÏ㽶ÊÓƵ expression to explain HIV-associated pathologies.
3. Analyzing virus-host molecular interactions in the regulation of the innate cell response to HIV infection in lymphocytes, monocytes and astrocytes in relationship with viral persistence in HIV-infected patients.
4. Function of TRBP-Dicer-Ago2 interactions in Ï㽶ÊÓƵ interference and cellular localization in mammalian cells.