香蕉视频

Synthetic biology is often defined as the reshuffling of Nature鈥檚 circuits on a genetic level but it could also involve the development of synthetic receptors that are sensitive to unnatural stimuli. Over the last decade, our group has systematically explored the conversion of proteins that normally respond to small molecules, heat, membrane tension, or voltage, into photoreceptors. We usually do this by attaching synthetic photoswitches with modern bioconjugation techniques that work in vivo. Using opioid receptors and dopamine receptors (family A), GLP1 receptors (family B), and mGluRs (family C) as examples, I will show how just about any receptor be converted into a photoreceptor.