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Abstract:

Despite the success of iron-based catalysts for transformations in organic chemistry, including cross-coupling and C-H functionalization reactions, a detailed molecular level understanding of these systems has remained elusive. This limitation is in stark contrast to palladium chemistry, where detailed studies of active catalyst structure and mechanism have provided the foundation for the continued design and development of catalysts with novel and/or improved catalytic performance. The use of an experimental approach combining advanced inorganic spectroscopies (M枚ssbauer, magnetic circular dichroism, electron paramagnetic resonance), density functional theory studies, synthesis and kinetic analyses enables the direct evaluation of the active iron species in iron catalyzed transformations in organic chemistry, providing a critical mechanistic framework to facilitate and inspire new iron-based methods development. This presentation will focus on our recent studies in organoiron intermediates in cross-coupling in both the presence and absence of supporting ligands, including the effect of the key additive NMP in achieving highly effective cross-coupling with alkyl Grignard reagent. In addition, recent studies on iron-catalyzed hydromagnesiation and C-H functionalization will also be discussed.

Bio:

Mike received his B.A. in chemistry from Colgate University in 1999. Following studies at the University of Cambridge as a Churchill Scholar, leading to an M.Phil. degree in chemistry, he moved to Stanford University where he received his Ph.D. in chemistry in 2007. At Stanford, Mike became interested in the use of physical-inorganic spectroscopic methods to understand transition metal catalytic systems in biological systems. Following brief stops at Dow Chemical as a Senior Research Chemist and Los Alamos National Laboratory as a Director鈥檚 Postdoctoral Fellow, Mike joined the Department of Chemistry at the University of Rochester in 2011 as an assistant professor. His research at Rochester focuses on the generation of new fundamental insight into structure, bonding and mechanism in homogeneous non-precious metal catalysis including iron-catalyzed cross-coupling and iron- and cobalt-catalyzed direct C-H functionalization. Further research interests include elucidation of electronic structure, bonding and mechanism in f-element chemistry.