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The Hannoush group is focused on developing pharmacological strategies for targeting proteins and protein – protein interactions that are important in disease, with the aim of developing novel therapeutics and at the same time advancing their understanding of cellular molecular mechanisms. Specific lab interests include Wnt signaling, protein lipidation, developing novel peptide technologies for drug discovery and lead identification, probe development and molecular imaging to study protein behavior in cells. Throughout this work, the lab utilizes a combination of phage display, biochemistry, chemical and cell biology approaches. They also identify and utilize peptides as proof-of-concept tools to study stem cell signaling pathways and to understand how to target tumors.