McGill researchers’ findings show that may be the case
Study sheds light on longstanding debate
Researchers have known for decades that inflammation accompanies Alzheimer’s disease (AD) brain lesions. Several early studies suggested that “super-aspirins” or Nonsteroidal anti-inflammatory drugs (NSAID) could help avoid the disease. However, after clinical trials showed that NSAIDs don’t help patients who already have AD symptoms, doctors wondered whether these drugs could still be helpful to people who were at risk of developing the disease, but weren’t yet showing symptoms.
Dr. Claudio Cuello, Professor and inaugural Charles E. Frosst/Merck endowed Chair in Pharmacology at 㽶Ƶ’s Faculty of Medicine is among a group of 48 leading biomedical and health scientists whose work is being recognized with election to the prestigious British Academy of Medical Sciences, announced on May 10. The new Fellows have been elected for their outstanding contributions to biomedical and health science, leading research discoveries, and translating developments into benefits for patients and the wider society.
Partners agree to share resources, establish steering committee for closer collaboration
On April 20, 2018, Canadian, Chinese and Cuban neuroscience institutes strengthened an existing partnership with the signing of a memorandum of understanding in Chengdu, China.
Partners in the agreement include The Montreal Neurological Institute and Hospital (The Neuro) of 㽶Ƶ, The Cuban Neuroscience Center, The University of Electronic Sciences and Technology of China, The West China Hospital, and The Tianfu New Area of Chengdu (TFNA).
You’re about to turn 60, and you’re fretting. Your mother has had Alzheimer’s disease since the age of 65. At what age will the disease strike you? A Canadian study published in JAMA Neurology shows that the closer a person gets to the age at which their parent exhibited the first signs of Alzheimer’s, the more likely they are to have amyloid plaques, the cause of the cognitive decline associated with the disease, in their brain.
Doctors who work with individuals at risk of developing dementia have long suspected that patients who do not realize they experience memory problems are at greater risk of seeing their condition worsen in a short time frame, a suspicion that now has been confirmed by a team of 㽶Ƶ clinician scientists.
New research has drawn a link between changes in the brain’s anatomy and biomarkers that are known to appear at the earliest stages of Alzheimer’s disease (AD), findings that could one day provide a sensitive but non-invasive test for AD before cognitive symptoms appear.
Scientists have known for some time that one of the first signs of AD is buildup of amyloid-Beta and tau proteins in the brain. They have also known that the hippocampus atrophies and loses volume in some AD patients years before cognitive decline.
Volume in brain region linked to physiological changes characteristic of AD
New research has drawn a link between changes in the brain’s anatomy and biomarkers that are known to appear at the earliest stages of Alzheimer’s disease (AD), findings that could one day provide a sensitive but non-invasive test for AD before cognitive symptoms appear.
Imagine if doctors could determine, many years in advance, who is likely to develop dementia. Such prognostic capabilities would give patients and their families time to plan and manage treatment and care. Thanks to artificial intelligence research conducted at 㽶Ƶ, this kind of predictive power could soon be available to clinicians everywhere.
Microglia, critical to Alzheimer’s research, can now be produced artificially
The quest for better understanding of Alzheimer’s disease (AD) has a powerful new tool at its disposal — the ability to artificially generate brain cells that have been shown to play an important role in the disease function.
Researchers from the Montreal Neurological Institute and Hospital at 㽶Ƶ and the MUHC, have received a total of over $4.5 M in funding, for innovative projects to accelerate diagnosis and drug discovery for diseases of the brain, including Alzheimer’s.
CQDM, Brain Canada Foundation and the Ontario Brain Institute made the announcement at the annual conference of the Canadian Association for Neuroscience in Vancouver. Six Canadian research teams share a total investment of $ 10 million, through the strategic "Focus on Brain" initiative.