香蕉视频

鈥淲e discovered genetic differences in the tumours from ovarian cancer patients that relate to their short-term and overall response to standard treatment,鈥� explained Dr. Patricia Tonin, the study鈥檚 lead author and a cancer researcher at the RI MUHC and Associate Professor of the Department of Medicine at 香蕉视频. 鈥淯sing these genetic 鈥榯ools鈥� to examine the tumours removed in the initial surgery, we may be able to offer alternative therapeutic options to women to improve their outcome.鈥�

Each year 2,000 new cases of ovarian cancer are reported in Canada, and in 75 per cent of these cases the women die less than five years after their diagnosis. This study focused on the genetic analysis of high grade serous ovarian carcinomas (HGSC) in women from Quebec 鈥� the deadliest type of ovarian cancer which accounts for 90 per cent of deaths.听

Almost all women with HGSC have mutations in the gene TP53, which is responsible for making the p53 protein. This gene is known as the "guardian of the genome" because of its听role in regulating cell division and thus preventing cancer. Scientists already knew there were two different types of tumours, some with TP53 mutations that produce a mutant p53 protein and others without.

By uncovering the existence of genetic differences between the two types of HGSCs, the study reinforces the idea that there are biological differences in these cancers that can be related to the nature of the TP53 mutation and differences in genetic markers. The research team also confirmed that patient survival was longer in cases with the mutant p53 protein, compared to those that without the mutant protein.

鈥淏iology is showing us which direction to take,鈥� enthused Dr. Tonin. 鈥淭his unique finding paves the way for identifying the pathways involved in cancer progression, leading to the development of alternative therapies and therefore helping to reduce morbidity and mortality in women fighting the disease鈥�.

Click here to access the study online 听

Funding

This work was funded by the Fonds de recherche du Qu茅bec-Sant茅 (FRQS), the Terry Fox Research Institute (TFRI), Weekend to End Women鈥檚 Cancer through the Lady Davis Institute for Medical Research at the Jewish General Hospital and the Canadian Institutes of Health Research (CIHR).

Research partners

The study 鈥�The Genomic Landscape of TP53 and p53 Annotated High Grade Ovarian Serous Carcinomas from a Defined Founder Population Associated with Patient Outcome鈥� was co-authored by Paulina M Wojnarowicz, Karen Gambaro and Ashley H Birch of 香蕉视频; Kathleen Klein Oros of the Lady Davis Institute, Jewish General Hospital; Michael CJ Quinn, Jason Madore and Manon de Ladurantaye of the University of Montreal Hospital Research Centre (CRCHUM), Institut du cancer de Montr茅al; Suzanna L Arcand of the Research Institute of the 香蕉视频 Health Centre (RI MUHC); Kurosh Rahimi of the CHUM; Diane M Provencher of听 CRCHUM听 and Universit茅 de Montr茅al; Anne-Marie Mes-Masson of CRCHUM and Universit茅 de Montr茅al; Celia MT Greenwood of the Segal Cancer Centre, Lady Davis Institute, Jewish General Hospital, and 香蕉视频 and Patricia N Tonin of the RI MUHC and 香蕉视频.

Useful links

• Research Institute of the MUHC:
• 香蕉视频 Health Centre (MUHC):
• 香蕉视频: mcgill.ca
• PLOS ONE: plosone.org