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Researchers find that influenza has an Achilles鈥� Heel
Flu epidemics cause up to half a million deaths worldwide each year, and emerging strains continually threaten to spread to humans and cause even deadlier pandemics. A study by 香蕉视频 professor Maziar Divangahi published by Cell Press on April 10 in the journal Immunity reveals that a drug that inhibits a molecule called prostaglandin E2 (PGE2) increases survival rates in mice infected with a lethal dose of the H1N1 flu virus. The findings pave the way for an urgently needed therapy that is highly effective against the flu virus and potentially other viral infections.
Published: 10 April 2014
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Persistent threat to human health
Despite the worldwide use of vaccination and other antiviral interventions, the flu virus remains a persistent threat to human health. To investigate molecular pathways that could be targeted by new interventions, Divangahi, an assistant professor in the Faculty of Medicine (Department of Microbiology and Immunology), and his team focussed on drugs such as aspirin and ibuprofen,听 commonly used to manage flu-like symptoms. By inhibiting a molecule called cyclooxygenase (COX), ibuprofen and other nonsteroidal anti-inflammatory drugs (NSAIDs) lower the production of five major prostanoids鈥攊mmune molecules that contribute to pain and fever.
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鈥淏ut since these drugs inhibit all prostanoids, each may contribute differently towards the immunity against influenza virus,鈥� says Francois Coulombe, a McGill Ph.D. student and the study鈥檚 first author. 鈥淯nderstanding their individual role is crucial in developing a new therapy.鈥澨�
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Enhanced antiviral immunity
Divangahi鈥檚 research team found that mice genetically engineered to lack a member of the prostanoid family, PGE2, showed remarkably enhanced immunity to flu infection. Most importantly, the vast majority of these mice infected with a lethal dose of the H1N1 flu virus survived. Similarly, mice treated with a compound that inhibits PGE2 showed enhanced antiviral immunity and produced better survival rates following infection with a lethal dose of the flu virus compared with untreated mice.
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鈥淧revious studies produced conflicting results due to the听听 inhibition of all prostanoids, not just PGE2,鈥� Divangahi says. 鈥淥ur findings suggest that different prostaglandins have different roles in antiviral immunity and that specific inhibition of PGE2 will be an effective therapy against influenza viral infection by boosting immune responses.鈥�
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Journal link: TO COME
IMAGE: H1N1 (Thinkstock)