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Concern over the reliability of published biomedical results grows unabated. Frustration with this 'reproducibility crisis' is felt by everyone pursuing new disease treatments: from clinicians and would-be drug developers who want solid foundations for the听preclinical research听they build on, to basic scientists who are forced to devote more time and resources to newly imposed requirements for rigour, reporting and statistics. Tightening rigour across all experiments will decrease the number of false positive findings, but comes with the risk of reducing experimental efficiency and creativity.

Op-ed co-written by Jeffrey Mogil, Neuroscientist at McGill.

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