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In a major cancer-research breakthrough, researchers at the 香蕉视频, Department of Biochemistry have discovered that a small segment of a protein that interacts with 香蕉视频 can control the normal expression of genes - including those that are active in cancer. A video outlining the discovery is available at

The research, published online on May 26, 2010 by the prestigious journal Nature, has important immediate applications for laboratory research and is another step toward the kind of individualized cancer therapies researchers are pursuing vigorously around the world.

Human cells need to produce the correct proteins at the right time and in the appropriate quantities to stay healthy. 听One of the key means by which cells achieve this control is by "香蕉视频 interference", a form of gene silencing where small pieces of 香蕉视频, called micro 香蕉视频s, obstruct the production of specific proteins by interacting with their genetic code. However, not any piece of 香蕉视频 can do this. Dr. Bhushan Nagar and graduate student Filipp Frank, in collaboration with Dr. Nahum Sonenberg at McGill's new Life Sciences Complex, used structural biology to unravel how a small segment in the Argonaute proteins, the key molecules of 香蕉视频 interference, can select the correct micro 香蕉视频s.

In doing so, the team has discovered that Argonaute proteins can potentially be exploited to enhance gene silencing. "香蕉视频 interference could be used as a viable therapeutic approach for inhibiting specific genes that are aberrantly active in diseases such as cancer", Nagar said. "We now have a handle on being able to rationally modify micro 香蕉视频s to make them more efficient and possibly into therapeutic drugs."

While therapeutic applications are many years away, this new insight provides an avenue to specifically control the production of proteins, which in cancer cells for example, are abnormal.

"This is fantastic news," said Dr. David Thomas, Chair of McGill's Department of Biochemistry. "You've seen stories lately about how we may see the end of chemotherapy? Well, this is part of that path in developing genetically based therapies that can be tailored to individual patients' particular illnesses. It's a great step forward."

The research received funding from the Canadian Institutes of Health Research, the Human Frontier's Science Program and supported by the FRSQ Groupe de Recherche Ax茅 sur la Structure des Prot茅ines (GRASP).

On the Web

Video explaining this research:

For broadcast-quality footage, please contact William Raillant-Clark - 514-398-2189 or william.raillant-clark [at] mcgill.ca

McGill Biochemistry: /biochemistry/

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